Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes

Musak, Ludovit; Souček, Pavel; Vodičková, Ľudmila; Naccarati, Alessio; Halašová, Erika; Polakova, Veronika; Slyšková, Jana; Šůsová, Simona; Buchancová, J; Šmerhovský, Zdeněk; Sedikova, Jana; Klimentova, Gabriela; Osina, Oto; Hemminki, Kari; Vodička, Pavel

doi:10.1016/j.mrfmmm.2008.02.007

Cited by 30 publications

(25 citation statements)

References 45 publications

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“…There was no general difference between the sexes for any type of CATot, in accordance with earlier studies (34,44,45), in contrast to micronuclei which showed a higher rate among women in a number of studies (44).…”

Section: Musak Et Alsupporting

confidence: 92%

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Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Musak¹,

Šmerhovský²,

Halašová³

et al. 2013

Scand J Work Environ Health

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We report significantly increased chromosomal damage among medical staff occupationally exposed to various genotoxic compounds in several medical professions. Potentially harmful exposures in hospital environment represent considerable health risk, since chromosomal aberrations have been found to be predictive of cancer risk, and an association between chromosomal damage and cancer risk has been shown. Affiliation:

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Section: Musak Et Alsupporting

confidence: 92%

“…The methodology for cytogenetic analysis has been described earlier (33,34) and was in accordance with existing guidelines (35). Briefly, peripheral blood lymphocytes stimulated to grow by phytohemagglutinin were cultured for 48 hours.…”

Section: Cytogenetic Analysismentioning

confidence: 99%

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Musak¹,

Šmerhovský²,

Halašová³

et al. 2013

Scand J Work Environ Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…In fact, the lack of association in the whole database described by Vodicka et al contrasts with the significant results reported in exposure-specific subsets, such as the highest frequency of CAs in GSTT1 -null smokers working in the tire industry (Musak et al 2008). This interpretation is also supported by the study of Iarmarcovai et al (2008a), who reviewed 72 population studies reporting a significant effect of GSTM1 , EPHX (microsomal epoxide hydrolase), and GSTT1 on micronucleus frequency.…”

mentioning

confidence: 64%

GST Polymorphisms: Bonassi et al. Respond

Bonassi

Hansteen

Rossi

et al. 2009

Environ Health Perspect

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“…PCR reactions were carried out according to the protocol of Musak et al (2008). The amplified fragments were digested with appropriate restriction endonucleases and analyzed.…”

Section: Genotyping Analysismentioning

confidence: 99%

Polymorphisms of DNA Repair Genes and Lung Cancer in Chromium Exposure

Šarlinová

Majerová

Matáková

et al. 2014

Advances in Experimental Medicine and Biology

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Chromium is a well known carcinogen involved in the lung cancer development. Polymorphism of some of the DNA repair genes may be associated with elevated risk of cancerous transformation. In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1(Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure. We analyzed 119 individuals; 50 patients exposed to chromium with diagnosed lung cancer and 69 healthy controls. Genotypes were determined by a PCR-RFLP method. We found a significantly increased risk of lung cancer development in XPD genotype Lys/Gln (OR=1.94; 95% CI=1.10-3.43; p=0.015) and in the gene combinations: XPD Lys/Gln+XPC Lys/Gln (OR=6.5; 95% CI=1.53-27.49; p=0.009) and XPD Lys/Gln+XPC Gln/Gln(OR=5.2; 95% CI=1.07-25.32; p=0.04). In conclusion, gene polymorphisms in the DNA repair genes may underscore the risk of lung cancer development in the chromium-exposed individuals.

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Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes

Cited by 30 publications

References 45 publications

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

GST Polymorphisms: Bonassi et al. Respond

Polymorphisms of DNA Repair Genes and Lung Cancer in Chromium Exposure

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