Chronic Spontaneous Urticaria Is Characterized by Lower Serum Advanced Glycation End-Products

Abstract

Background. Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response. On the other hand, it is known that systemic inflammation may lead to increased formation of advanced glycation end-products (AGEs), associated with pathogenesis of various diseases. Aim. We aim to test whether chronic inflammation manifested by activated acute phase response may provide a mechanism for increased serum AGEs concentration in CSU. Methods. Concentrations of AGEs were measured spectrofluorimetrically in serum of CSU patients and the healthy subjects. Results. Serum AGEs and albumin concentrations in CSU patients were significantly lower as compared with the healthy subjects. Serum CRP concentration was significantly higher in patients with CSU than in the controls. Significant positive correlation was observed between AGEs and albumin concentrations in the subjects. Conclusions. CSU is not associated with increased circulating AGEs concentrations, despite the enhanced systemic inflammatory response. Paradoxical decrease of serum AGEs concentrations is probably a reflection of lower concentration of “negative acute phase proteins” such as albumin.

Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria

“…37 patients with active CSU (26 women and 11 men; mean age: 39 ± 9.5 years) with a median disease duration of 2.9 years were enrolled in the study, as described previously [ 13 ].…”

“…CRP concentration in moderate-severe CSU group was significantly higher than in mild CSU group and the healthy subjects (median 10.30 vs. 1.2 vs. 1.02 mg/l, p < 0.00001). There was no significant difference in serum CRP concentration between patients with mild CSU and the control group (median 1.2 vs. 1.02 mg/l, p = 0.07) [ 13 ].…”

“…In our previous study, we observed lower AEGs concentration in serum of CSU patients, despite the enhanced systemic inflammatory response. Paradoxical decrease of serum AGEs concentrations is probably a reflection of lower concentration of the ‘negative acute phase proteins’, such as albumin [ 13 ]. It seems interesting to perform further investigations of the RAGE signaling system in the disease.…”

Ocena stężenia produków zaawansowanej glikacji białek i przeciwciał anty-CEL i anty-CML w surowicy pacjentów chorujących na orbitopatię Gravesa przed i po leczeniu metyloprednizolonem

“…In contrast, serum AGE concentrations in chronic spontaneous urticarial (CSU) patients were significantly lower as compared with the healthy subjects [19]. Plasma soluble receptor for advanced glycation end products (sRAGE) may serve as a potential biomarker for disease activity and a future therapeutic target in systemic lupus erythematosus (SLE) [20].…”

“…Studies on animals have shown that the levels of the glycation product N-e-fructose lysine (FL) and CML identified by GC/MS in liver proteins decreased significantly in hyperthyroid rats, proving that thyroid hormones influence this process [21]. Due to the increasing interest in the usage of various receptors for advanced glycation end products (RAGE) (especially those being expressed on the surface of monocytes) as potential therapeutic targets in the states of inflammation and autoimmunisation [20], like GO, it is essential to examine the process of glycation in that state.…”