Chronic suppurative otitis media: A review

Verhoeff, Monique; Veen, Erwin L. van der; Rovers, Maroeska M.; Sanders, Elisabeth A. M.; Schilder, Anne G. M.

doi:10.1016/j.ijporl.2005.08.021

Cited by 284 publications

(256 citation statements)

References 99 publications

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“…Chronic suppurative otitis media was defined as otorrhoea through a perforated tympanic membrane, present for at least two to six weeks. 4,11 Ethical committee approval was obtained before starting the study. In addition, all 185 enrolled patients signed informed consent forms.…”

Section: Introductionmentioning

confidence: 99%

A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media

et al. 2017

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Objective: To assess the frequency of bacterial agents in chronic suppurative otitis media and the antibiotic susceptibility patterns of isolates among patients.Methods: A total of 185 patients clinically diagnosed with chronic suppurative otitis media were interviewed and middle-ear effusion samples were collected using sterile swabs. All bacterial isolates were identified by conventional microbiological methods. Antibiotic susceptibility patterns of the isolates were determined by Kirby-Bauer disc diffusion.Results: Staphylococci spp. (64.9 per cent) were the most prevalent bacteria isolated, followed by Klebsiella spp. (12.9 per cent) and Pseudomonas aeruginosa (10.3 per cent). The most effective antibiotic for treatment of bacterial chronic suppurative otitis media was ciprofloxacin. Statistical analysis showed no significant difference in bacterial infestations among chronic suppurative otitis media patients and the antimicrobial susceptibility patterns of the bacterial isolates based on gender and age ( p > 0.05).Conclusion: Our findings highlight the importance of a continuous and periodic evaluation of the bacteriological profile and antibiotic susceptibility patterns in chronic suppurative otitis media patients for efficacious treatment of the infection.

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Section: Introductionmentioning

confidence: 99%

A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media

et al. 2017

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“…[10][11][12][13][14]16 Inclusion and outcome criteria, route of drug administration, and follow-up periods in those studies varied considerably, and no study was placebo controlled. 2 Our results need to be interpreted in light of several limitations. First, the children in our study had persistent symptoms of COM despite conventional management with topical medications, short-term systemic antibiotic therapy, and/or previous ear surgery.…”

Section: Discussionmentioning

confidence: 91%

“…[1][2][3] It causes considerable morbidity and is a major global cause of hearing impairment in children. Moreover, it may lead to serious extracranial and intracranial complications, such as mastoiditis and meningitis.…”

mentioning

confidence: 99%

Effectiveness of Trimethoprim/Sulfamethoxazole for Children With Chronic Active Otitis Media: A Randomized, Placebo-Controlled Trial

Veen¹,

Rovers

Albers³

et al. 2007

Pediatrics

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OBJECTIVE. The goal was to determine the clinical effectiveness of prolonged outpatient treatment with trimethoprim/sulfamethoxazole for children with chronic active otitis media. METHODS. We performed a randomized, placebo-controlled trial with 101 children (1–12 years of age) with chronic active otitis media (defined as otorrhea for ≥12 weeks). In addition to a short course of steroid and antibiotic eardrops, children were assigned randomly to receive 6 to 12 weeks of orally administered trimethoprim/sulfamethoxazole (18 mg/kg, 2 times per day) or placebo and were monitored for 1 year. RESULTS. At 6 weeks, 28% of children in the trimethoprim/sulfamethoxazole group and 53% of children in the placebo group had otomicroscopic signs of otorrhea. At 12 weeks, these values were 32% and 47%, respectively. At 1 year, the numbers of children with otorrhea were similar in the 2 groups (25% and 20%, respectively). One child in the trimethoprim/sulfamethoxazole group developed a skin rash. Vomiting or diarrhea was reported for 9% of the trimethoprim/sulfamethoxazole group and 2% of the placebo group. Pure-tone hearing levels and health-related quality of life improved during the study but did not differ between the trimethoprim/sulfamethoxazole group and the placebo group. Pseudomonas aeruginosa was the most frequently isolated bacteria in the otorrhea samples from both groups. CONCLUSIONS. A 6- to 12-week course of high-dose, orally administered trimethoprim/sulfamethoxazole therapy is beneficial for children with chronic active otitis media. The treatment effect is most pronounced with the shorter course and disappears if administration of the medication is discontinued.

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“…Moreover, the COM pathogenesis is multifactorial: environmental factors, genetically determined factors and functional/anatomical characteristics of the Eustachian Tube, all play a role 13 . G (IgG) and A (IgA) immunoglobulins are important in the defense mechanisms against COM.…”

Section: Chronic Otitis Mediamentioning

confidence: 99%

Impacto da Haart na prevalência de otite média crônica em crianças brasileiras infectadas pelo HIV

Weber

Pinheiro‐Neto

Miziara

et al. 2006

Rev. Bras. Otorrinolaringol.

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O advento de novas drogas anti-retrovirais como os inibidores de protease provocou mudanças sensíveis na morbidade e mortalidade de pacientes infectados pelo HIV. OBJETIVOS: Avaliar o impacto das novas drogas anti-retrovirais (Highly Active Anti-retroviral Therapy - HAART) na prevalência de otite média crônica em população pediátrica infectada pelo HIV. MÉTODOS: Analisamos os prontuários de 471 crianças com idade entre zero e 12 anos e 11 meses portadoras de HIV atendidas no ambulatório de AIDS de Clínica Otorrinolaringológica do HCFMUSP. As crianças foram divididas em dois grupos, de acordo com a faixa etária: 0 a 5 anos e 11 meses e 6 a 12 anos e 11 meses, e classificadas como portadoras de otite média crônica, baseadas em achados de anamnese, otoscopia, audiometria e imitanciometria. As prevalências de otite média crônica apresentadas e as contagens de linfócitos T CD4+ foram comparadas entre as crianças em uso ou não de HAART. RESULTADOS: Das 459 crianças atendidas, 65 (14,2%) apresentavam otite média crônica. Observamos, nas crianças de 0 a 5 anos e 11 meses que o uso de HAART esteve associado a significante menor prevalência de otite média crônica (p = 0,02), e maior contagem de linfócitos T CD4+ (p < 0,001). CONCLUSÃO: O uso de HAART esteve associado à menor prevalência da forma crônica de otite média entre crianças menores de 6 anos infectadas pelo HIV, provavelmente como conseqüência do aumento promovido na contagem de linfócitos T CD4+.

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Chronic suppurative otitis media: A review

Cited by 284 publications

References 99 publications

A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media

A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media

Effectiveness of Trimethoprim/Sulfamethoxazole for Children With Chronic Active Otitis Media: A Randomized, Placebo-Controlled Trial

Impacto da Haart na prevalência de otite média crônica em crianças brasileiras infectadas pelo HIV

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