Circadian variation of strain differences in body temperature and activity in mice

Connolly, Michael S.; Lynch, Carol Becker

doi:10.1016/0031-9384(81)90368-1

Cited by 39 publications

(14 citation statements)

References 16 publications

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“…Repeatability of individual di erences in body temperature was higher at night than during the day (Table 1). The heritability estimates of body temperature reported by Connolly and Lynch (1981) are consistent with this pattern: higher at night than during the day (note, however, that they did not correct for possible e ects of di erences in activity levels). If body temperature is heritable, then it has the potential to respond in a cor-related fashion to selection on wheel running.…”

Section: Discussionmentioning

confidence: 58%

“…Few studies, however, have focused on body temperature di erences among individual animals (Hayes and Jenkins, 1997) or among populations within a single species (Garland and Adolph, 1991). Connolly and Lynch (1981) measured body tempera-ture around the clock in four di erent inbred strains of mice to estimate broad-sense heritability (ratio of total genetic variance to phenotypic variance). Heritability of body temperature measured during the day, when mice were sleeping, was lower than at night, when they were active.…”

Section: Introductionmentioning

confidence: 99%

“…Heritability of body temperature measured during the day, when mice were sleeping, was lower than at night, when they were active. Interestingly, the strains that di ered most in body temperature have also been shown to di er in locomotor activity: BALB/c mice were more active in their cages than C57BL/6 (Lassalle and Le Pape, 1978) and displayed approximately 18C higher body temperature at night (Connolly and Lynch, 1981). Arti®cial selection is one tool that can be used to study the genetics and correlated evolution of di erent aspects of the phenotype (Garland and Carter, 1994;Gibbs, 1999;Ro , 1997).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection

Rhodes

Koteja

Swallow

et al. 2000

Journal of Thermal Biology

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection

Rhodes

Koteja

Swallow

et al. 2000

Journal of Thermal Biology

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“…Another issue in this study was that all behavioral tests were performed during the light period. Mice are nocturnal animals and they have a lower body temperature and lower activity in the open-field during the light phase than during the dark phase (Connolly and Lynch 1981). This factor should be considered in the interpretation of the results.…”

Section: Discussionmentioning

confidence: 99%

Genetic Mapping of Social Interaction Behavior in B6/MSM Consomic Mouse Strains

et al. 2009

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Genetic studies are indispensable for understanding the mechanisms by which individuals develop differences in social behavior. We report genetic mapping of social interaction behavior using inter-subspecific consomic strains established from MSM/Ms (MSM) and C57BL/6J (B6) mice. Two animals of the same strain and sex, aged 10 weeks, were introduced into a novel open-field for 10 min. Social contact was detected by an automated system when the distance between the centers of the two animals became less than ~12 cm. In addition, detailed behavioral observations were made of the males. The wild-derived mouse strain MSM showed significantly longer social contact as compared to B6. Analysis of the consomic panel identified two chromosomes (Chr 6 and Chr 17) with quantitative trait loci (QTL) responsible for lengthened social contact in MSM mice and two chromosomes (Chr 9 and Chr X) with QTL that inhibited social contact. Detailed behavioral analysis of males identified four additional chromosomes associated with social interaction behavior. B6 mice that contained Chr 13 from MSM showed more genital grooming and following than the parental B6 strain, whereas the presence of Chr 8 and Chr 12 from MSM resulted in a reduction of those behaviors. Longer social sniffing was observed in Chr 4 consomic strain than in B6 mice. Although the frequency was low, aggressive behavior was observed in a few pairs from consomic strains for Chrs 4, 13, 15 and 17, as well as from MSM. The social interaction test has been used as a model to measure anxiety, but genetic correlation analysis suggested that social interaction involves different aspects of anxiety than are measured by open-field test.Electronic supplementary materialThe online version of this article (doi:10.1007/s10519-009-9312-x) contains supplementary material, which is available to authorized users.

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“…One-month-old male RGS2 Ϫ/Ϫ and control C57BL/6 wild-type (WT) mice were anesthetized with an intraperitoneal injection of a mixture of ketamine (150 mg/kg) and xylazine (10 mg/kg) and fixed in a supine position over a heated water blanket. Body temperature was monitored with a YSI-402 (Yellow Springs Instruments, Yellow Springs, OH) small animal rectal probe inserted ϳ1 cm past the anal sphincter and maintained within the normal physiological range (36.5-38°C) (8). Hair was removed from the neck with Nair cream hair remover (Church & Dwight, Mississauga, ON, Canada).…”

Section: Methodsmentioning

confidence: 99%

Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse

Tuomi¹,

Chidiac²,

Jones

2010

American Journal of Physiology-Heart and Circulatory Physiology

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Atrial fibrillation (AF) is the most common arrhythmia seen in general practice. Muscarinic ACh receptors (M2R, M3R) are involved in vagally induced AF. M2R and M3R activate the heterotrimeric G proteins, G(i) and G(q), respectively, by promoting GTP binding, and these in turn activate distinct K(+) channels. Signaling is terminated by GTP hydrolysis, a process accelerated by regulator of G protein signaling (RGS) proteins. RGS2 is selective for G(q) and thus may regulate atrial M3R signaling. We hypothesized that knockout of RGS2 (RGS2(-/-)) would render the atria more susceptible to electrically induced AF. One-month-old male RGS2(-/-) and C57BL/6 wild-type (WT) mice were instrumented for intracardiac electrophysiology. Atrial effective refractory periods (AERPs) were also determined in the absence and presence of carbachol, atropine, and/or the selective M3R antagonist darifenacin. Susceptibility to electrically induced AF used burst pacing and programmed electrical stimulation with one extrastimulus. Real-time RT-PCR measured atrial and ventricular content of RGS2, RGS4, M2R, M3R, and M4R mRNA. AERP was lower in RGS2(-/-) compared with WT mice in both the high right atrium (HRA) (30 +/- 1 vs. 34 +/- 1 ms, P < 0.05) and mid right atrium (MRA) (21 +/- 1 vs. 24 +/- 1 ms, P < 0.05). Darifenacin eliminated this difference (HRA: 37 +/- 2 vs. 39 +/- 2 ms, and MRA: 30 +/- 2 vs. 30 +/- 1, P > 0.4). RGS2(-/-) were more susceptible than WT mice to atrial tachycardia/fibrillation (AT/F) induction (11/22 vs. 1/25, respectively, P < 0.05). Muscarinic receptor expression did not differ between strains, whereas M2R expression was 70-fold higher than M3R (P < 0.01). These results suggest that RGS2 is an important cholinergic regulator in the atrium and that RGS2(-/-) mice have enhanced susceptibility to AT/F via enhanced M3 muscarinic receptor activity.

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Circadian variation of strain differences in body temperature and activity in mice

Cited by 39 publications

References 16 publications

Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection

Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: repeatability and effect of genetic selection

Genetic Mapping of Social Interaction Behavior in B6/MSM Consomic Mouse Strains

Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse

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