Classical and alternative pathway haemolytic activities of ovine complement: Variations with age and sex

Oswald, Isabelle P.; Lantier, Frédéric; Bourgy, G.

doi:10.1016/0165-2427(90)90041-p

Cited by 23 publications

(14 citation statements)

References 12 publications

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Section: Weaning Periodsupporting

confidence: 51%

“…Unfortunately, the complement system activity during weaning has not been deeply described in ruminants (cow, sheep and goat). Nevertheless, Oswald et al (1990) described the complement system activity (TCA and ACA) in lambs, showing a similar evolution to present results, although different values were described, probably due to differences in the analytical techniques used.In conclusion, lambs that received an amount of colostrum equivalent to 8 g of IgG/kg of BW equally divided into three meals at 2, 14 and 24 h after birth were able to reach similar IgG and greater IgM concentrations in blood than lambs reared under natural conditions during the first few days after birth. Lambs from the NR system obtained greater complement system activity than those from the artificial rearing system during the same period.…”

supporting

confidence: 51%

“…The complement system activity -comprising the total (TCA) and alternative (ACA) pathways -plays an important role in host defense mechanisms against infectious microbes, because it is involved in specific and non-specific immunity (Rodríguez et al, 2009;Hernández-Castellano et al, 2015b). There are few studies about the complement system activity in sheep and lambs, with the exception of the study published by Hernández-Castellano et al (2015b) and Hernández-Castellano et al (2015c), as these studies are based on an old determination technique (Oswald et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Hernández-Castellano

Suárez-Trujillo

Martell-Jaizme

et al. 2015

Animal

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The aim of this study was to investigate the BW and immune status of lambs reared under natural conditions or under artificial conditions fed two different colostrum amounts. In this study, 60 lambs were randomly divided into groups according to treatment. Twenty lambs remained with their dams (natural rearing (NR) group). Forty lambs were removed from their dams at birth. Lambs were bottle-fed with a pool of sheep colostrum, receiving either 4 g of IgG/kg of BW at birth (C4 group) or 8 g of IgG/kg of BW at birth (C8 group). The total colostrum amount was equally divided into three meals at 2, 14 and 24 h after birth. After this period, lambs were bottle-fed a commercial milk replacer. Blood plasma sample analysis and BW recordings were carried out before feeding at birth and then at 1, 2, 3, 4, 5 and 20 days after birth. Another blood sample analysis and BW recording was carried out when animals reached 10 kg of BW. During weaning (30 days), sampling was carried out every 5 days. Blood plasma was used to determine the concentrations of IgG and IgM and the complement system activity -total and alternative pathways. The NR group showed greater BW than the C4 and C8 groups during milk feeding period, whereas the C4 and C8 groups had greater BW than the NR group at the end of weaning period. The C8 and NR groups had greater plasma IgG and IgM concentrations than the C4 group during milk feeding period. In addition, C4 and C8 groups showed similar IgG concentrations and greater IgM concentrations than the NR group at the end of the weaning period. Complement system activity was greater in the NR group than in the C4 and C8 groups during the first 3 days after birth. In conclusion, lambs fed amounts of colostrum equivalent to 8 g of IgG/kg of BW showed similar immune variables compared to lambs reared under natural conditions, obtaining a greater BW at the end of the weaning period. Nevertheless, this study shows that not only the colostrum amount but also the management during the milk feeding and weaning period, such as stress produced by dam separation, milk quality and suckling frequency, can affect the final immune status of lambs.Keywords: immune, lamb, colostrum, weaning, artificial rearing ImplicationsColostrum plays a fundamental role in the immunization of newborn ruminants. Artificial rearing is a common method used in dairy farms, increasing the amount of milk for processing. The aim of this study was to feed newborn lambs colostrum with two different IgG concentrations and to compare these animals to natural dam fed lambs. This study showed that administration of 8 g of immunoglobulin g/kg BW at birth, equally divided into three colostrum meals (2, 14 and 26 h), achieved higher circulating immunoglobulin G concentration when compared to the natural rearing treatment, although both artificial rearing groups decreased BW after birth. IntroductionThe relationship between colostrum and the survival of newborn ruminants has been long characterized (Argüello et al., 2004;Castro et al., 2011;Abdou et al., 2014)...

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Section: Weaning Periodsupporting

confidence: 51%

supporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

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The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Hernández-Castellano

Suárez-Trujillo

Martell-Jaizme

et al. 2015

Animal

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“…From these results we concluded that it is not the number of FDC that is affected by age, but their capacity to trap and retain Ag. Nevertheless, old FDC do express substantial levels FcR and C' receptors and no deficits in complement have been reported in aged individuals suggesting that the lack of immune retention is not likely attributable to a lack of complement [31][32][33]. Thus, as supported by data in Fig.…”

Section: Discussionsupporting

confidence: 65%

Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation

et al. 2002

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“…Recently Pandey et aL (1993) found that there is very little loss of activity at -70°C by complement in cattle and sheep sera after 4 months but that at -20°C or -10°C these sera cannot be stored for more than one month without significant loss in complement activity. It is also possible that the method of handling blood and sera from collection until transfer to low temperatures for storage influences the stability of complement (Oswald et al, 1990). To our knowledge, there is no published report on the effect on complement activity of the temperature at which chicken sera are stored.…”

Section: Introductionmentioning

confidence: 88%

The effect of storage at low temperature on the haemolytic complement activity of chicken serum

et al. 1993

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Classical and alternative pathway haemolytic activities of ovine complement: Variations with age and sex

Cited by 23 publications

References 12 publications

The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

The effect of colostrum period management on BW and immune system in lambs: from birth to weaning

Age-related depression of FDC accessory functions and CD21 ligand-mediated repair of co-stimulation

The effect of storage at low temperature on the haemolytic complement activity of chicken serum

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