Clickable and smart drug delivery vehicles accelerate the healing of infected diabetic wounds

Deng, Miao; Wu, Ye; Ren, Yimin; Song, Haoyang; Zheng, Lei; Lin, Guangzhi; Wen, Xin; Tao, Yiran; Kong, Qingquan; Wang, Yu

doi:10.1016/j.jconrel.2022.08.053

Cited by 42 publications

(30 citation statements)

References 68 publications

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“…Recently, smart hydrogels with stimulus-responsive functions have attracted considerable attention. Briefly, stimulus-responsive hydrogels can respond to internal physiological signals (i.e., temperature [ 28 , 29 ], pH [ 30 , 31 ], redox [ 32 , 33 ], glucose [ 34 , 35 ], or enzymes [ 36 , 37 ]), external stimuli (i.e., temperature [ 38 , 39 ], magnetic field [ 40 , 41 ], pressure [ 42 , 43 ], reactive oxygen species (ROS) [ 44 , 45 ], light [ 46 , 47 ] and electric field [ 48 , 49 ]) or a combination of the above, which can reversibly or irreversibly change the physical properties or chemical structure ( Fig. 2 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in responsive hydrogels for diabetic wound healing

Zhang

Qin

et al. 2023

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

Recent advances in responsive hydrogels for diabetic wound healing

Zhang

Qin

et al. 2023

Materials Today Bio

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“…� Encourage angiogenesis and collagen deposition for accelerated wound healing. [115] ROS responsive ROS Hyaluronic acid network with ferrocene and β-CD moieties, loaded with natural herb.…”

Section: Infected Acute Woundmentioning

confidence: 99%

“…Copyright 2022 Elsevier. [115] the potential to prevent further deterioration of wound conditions. This would greatly help in wound management and improve the healing conditions of diabetic patients.…”

Section: Ph-responsive Wound Dressingmentioning

confidence: 99%

Responsive hydrogel dressings for intelligent wound management

Wang

Yeo

et al. 2023

BMEMat

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Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a complicated and dynamic physiological process with distinct molecular and cellular levels at each phase. Despite numerous strategies and advanced wound dressings being developed, successful wound management through smart dressing materials that can adapt to changing wound microenvironments and address the needs of wounds at different stages remains a big challenge. Over the last decade, hydrogel‐based dressings have emerged as one of the most potent biomaterials for wound treatment with favorable biological characteristics and a high potential for active intervention during the wound‐curing process. In the current contribution, we present the most recent progress in smart hydrogel dressings that can regulate the release of therapeutics in response to external stimuli (such as light) as well as endogenous changes in wound environments (e.g., temperature, pH, glucose, and reactive oxygen species) to facilitate wound healing. We also introduce the cutting‐edge technologies of intelligent “sense‐and‐treat” dressings through a combination of built‐in sensors or sensing molecules with responsive hydrogels, which enable real‐time monitoring of wound conditions and prompt on‐demand therapy.

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“…Mesoporous manganese dioxide has unique properties of alleviating localized hypoxia by inducibly promoting the decomposition of H 2 O 2 present in inflammatory settings [ 90 ]. A hydrogel encapsulated with mesoporous manganese dioxide can relieve localized oxidative stress and prolonged oxygen deprivation via effective oxygen generation [ 91 ]. Mesoporous manganese dioxide also can help composite hydrogels achieve satisfactory glutathione/pH/thermal-responsive controlled drug release in the tumor microenvironment, which is attributed to the fact that manganese dioxide is a redox-active material and can be degraded under glutathione, H 2 O 2 , and acid conditions [ 64 , 92 ].…”

Section: Classification Of Mesoporous Material-loaded Composite Hydro...mentioning

confidence: 99%

“…Co-encapsulation with metformin-loaded mesoporous silica microspheres and silver nanoparticles promoted fibroblast migration and endothelial cell angiogenesis in vivo via spatiotemporal immunomodulation [ 142 ]. The encapsulation of ultrasmall Ag nanoclusters and deferoxamine-loaded polydopamine/hollow mesoporous manganese dioxide nanoparticles in hydrogels effectively alleviated localized oxidative stress and facilitated the healing of infected wounds through the sequential engagement of antibacterial, anti-inflammatory, and proangiogenic activities [ 91 ].…”

Section: Application Of Mesoporous Material-loaded Composite Hydrogelsmentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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Clickable and smart drug delivery vehicles accelerate the healing of infected diabetic wounds

Cited by 42 publications

References 68 publications

Recent advances in responsive hydrogels for diabetic wound healing

Recent advances in responsive hydrogels for diabetic wound healing

Responsive hydrogel dressings for intelligent wound management

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

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