Clinical characteristics and insulin independence of Koreans with new‐onset type 2 diabetes presenting with diabetic ketoacidosis

Abstract

New-onset T2D patients presenting with DKA was not uncommon among the Korean population. In contrast to previously diagnosed T2D patients presenting with DKA, who showed a progressive decrease in insulin secretory function, new-onset KPD-T2B patients recovered insulin secretory function over time, and insulin independence could be expected.

Glucocorticoids did not reverse type 1 diabetes mellitus secondary to pembrolizumab in a patient with metastatic melanoma

“…However, a subset of patients with type 2 diabetes are also prone to ketosis, known as ‘ketosis prone type 2 diabetes’ 6. These patients are typically middle aged, have a family history of type 2 diabetes and may have markers suggesting insulin resistance such as obesity or acanthosis nigricans 7. Autoantibodies are typically negative.…”

Ketosis Onset Type 2 Diabetes Had Better Isletβ-Cell Function and More Serious Insulin Resistance

“…Most them were diagnosed as type 2 diabetes, who had good glucose control, did not need insulin treatment later during long time followup, and were lacking autoimmune markers of β -cell destruction [1–3]. Ketosis onset T2DM was considered as an atypical form of diabetes which was first reported in subjects of African origin.…”

“…Ketosis onset T2DM was considered as an atypical form of diabetes which was first reported in subjects of African origin. It was characterized by obesity, unprovoked ketoacidosis, reversible β -cell dysfunctions, and near-normoglycemic remission [4], but now it is widely recognized in several ethnical populations [1, 2, 5]. Some studies have compared islet β -cell function among those groups with typical T2DM or T1DM or nondiabetic subjects, but they have not obtained uniform conclusions so far [1–3, 6].…”

“…It was characterized by obesity, unprovoked ketoacidosis, reversible β -cell dysfunctions, and near-normoglycemic remission [4], but now it is widely recognized in several ethnical populations [1, 2, 5]. Some studies have compared islet β -cell function among those groups with typical T2DM or T1DM or nondiabetic subjects, but they have not obtained uniform conclusions so far [1–3, 6]. Gosmanov et al [6] showed that patients with ketosis-prone diabetes displayed a pattern of insulin secretion similar to that of patients with ketosis-resistant T2DM and obese nondiabetic subjects after hyperglycemia remission, but other researches have reported that non-insulin-dependent ketosis-prone T2DM showed lower C-peptide than that of typical T2DM after correction of hyperglycemia and ketosis [4].…”

Changes in circulating adiponectin, leptin, glucose and C‐peptide in patients with ketosis‐prone diabetes

“…The syndrome of ketosisprone diabetes (KPDM) represents atypical diabetes; patients with this syndrome present with diabetic ketoacidosis but do not fit the classic definition of Type 1 diabetes. It was initially recognized in African-American and Hispanic people in the USA but, during the past decade, it has been increasingly recognized and reported in other ethnic groups (such as Chinese, Korean, Hispanic and white people) [13,19]. It was initially recognized in African-American and Hispanic people in the USA but, during the past decade, it has been increasingly recognized and reported in other ethnic groups (such as Chinese, Korean, Hispanic and white people) [13,19].…”