Clinical study of multiple primary and double cancers including oral squamous cell carcinoma

Yamamoto, Nobuharu; Okubo, Taketo; Sakuma, Takumi; Sugahara, Kazuyuki; Yamamoto, Masae; Muramatsu, Kanji; Watanabe, Akira; Yakushiji, Takashi; Nomura, Takeshi; Takano, Nobuo; Shibahara, Takahiko

doi:10.1016/j.ajoms.2012.01.016

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Improvements in the cancer cure rate due to advancements in early diagnosis and treatment, extension of life expectancy, genetic disposition, exposure to several dietary and environmental carcinogens, hormonal imbalance, impaired host immunosurveillance, radiation carcinogenesis and oncogenic virus infection tends to increase the incidence of double and multiple primary cancers, in which two or more cancers occur in the same individual (6). The measures for multiple primary cancers as defined by Warren and Ehrenreich (7) in 1944 are: i) the two neoplasms must be malignant, ii) the two neoplasms must be anatomically separated and not connected by epithelial or submucosal neoplastic changes and iii) the possibility of the second tumor representing a metastasis from the index tumor must be excluded.…”

Section: Introductionmentioning

confidence: 99%

Clinical features of multiple primary carcinomas of the oral cavity

Li¹,

Ma²,

Han³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to elucidate the clinical characteristics of multiple primary carcinomas of the oral cavity. The clinical records of 1,024 patients who were treated during follow-up for oral cancer at the Department of Stomatology, Henan Provincial People's Hospital, between March 2013 and December 2014 were retrospectively reviewed. The clinical characteristics of 961 patients who developed single primary oral squamous cell carcinoma (SCC) during follow-up and 54 patients who subsequently developed multiple primary carcinomas in the oral cavity were compared. Multiple primary carcinomas exhibited a female predilection, were most prevalent in the gingiva, and tended to show earlier tumor and nodal stages, as compared with single primary carcinomas. The local recurrence rate was higher for multiple primary carcinomas, as compared with single primary carcinomas, and was demonstrated to increase with the number of multiple primary occurrences. The cumulative incidence rates for metachronous second primary carcinomas following the onset of the first carcinoma at 10 years was 8.0%. Recurrence of multiple primary carcinomas did not decrease the survival rates of the patients assessed in the present study. Furthermore, differences were detected in the clinical characteristics between patients with single oral SCC and those with multiple primary oral carcinomas. The results of the present study indicated that early diagnosis and treatment and close long-term follow-up are required for patients with multiple primary oral carcinomas.

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Section: Introductionmentioning

confidence: 99%

Clinical features of multiple primary carcinomas of the oral cavity

Li¹,

Ma²,

Han³

et al. 2016

Experimental and Therapeutic Medicine

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“…Recent years have seen an increase in the frequency of multiple primary cancers in oral cancer patients 13) . The present results showed that 10.7% of the patients developed double cancer, and 1 case of triple cancer was also observed.…”

Section: Discussionmentioning

confidence: 99%

“…A pathological classification of squamous cell carcinoma was observed in over 90% of the cases reviewed, indicating the importance of radiation therapy. However, because oral cancer is prone to develop into cervical lymph node metastases, surgery is the primary method of treatment 13) . The prognosis of each stage was as follows: the 5-year survival rate was 70-90% in stage I 1,6,7,10,14) , 60-80% in stage II 1,6,7,10,14) , 50-90% in stage III 6,7,10,14) , and 0-40% in stage IV 1,6,7,10,14) .…”

Section: Discussionmentioning

confidence: 99%

A 5-year Activity Report from the Oral Cancer Center, Tokyo Dental College

Yamamoto

Sato

Yamauchi

et al. 2013

Bull. Tokyo Dent. Coll.

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The Tokyo Dental College Oral Cancer Center was established on April 1st, 2006 at our Ichikawa General Hospital for the purpose of providing multimodal treatment for oral cancer. This report summarizes the Center's activities over the last 5 years. The total number of oral cancer patients treated was 360 (April 2006 to March 2011), with 205 primary cases. We investigated the following treatment-related items: 1) site, 2) age, 3) sex, 4) pathological examination, 5) staging, 6) systemic disorder, 7) double cancer, 8) treatment, and 9) prognosis. Out of 205 patients, 60% were men and 40% were women. Men in their 60s and women in their 80s were seen the most. The most common site was the tongue, at 42%, followed by the mandibular gingiva, maxillary gingiva, oral floor, and buccal mucosa. Squamous cell carcinomas were seen most frequently, at 94% (15% were stage I, 33% stage II, 15% stage III, and 34% stage IV). The most common treatment method was surgical treatment, at 83%. The 5-year survival rate at all stages was 85.4%. At the Oral Cancer Center, oral surgeons take the initiative in establishing treatment in cooperation with other departments and branches. Since the establishment of the Ambulatory Center for Maxillary Prosthetics in October 2011, 26 patients have undergone treatment. Related departments and branches work in teams, enabling comprehensive treatment, from the preoperative state to postoperative functional recovery. We wish to use these strengths to improve oral cancer treatment in Japan and will continue to work toward providing the best possible care for our patients.

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Clinical study of multiple primary and double cancers including oral squamous cell carcinoma

Cited by 2 publications

References 21 publications

Clinical features of multiple primary carcinomas of the oral cavity

Clinical features of multiple primary carcinomas of the oral cavity

A 5-year Activity Report from the Oral Cancer Center, Tokyo Dental College

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