Clinico Hematological Profile and Phase Distribution of Chronic Myeloid Leukemia

Chang, Farzana; Qazi, Riaz Ahmad; Khan, Mehrab; Baloch, Sarmad

doi:10.4172/0974-8369.1000257

Cited by 11 publications

(14 citation statements)

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“…Females were in lower proportion (n=38). Similar findings were also reported by Bhatti et al 14 Majority of our patients (n=66) were in the age group between 21 -50 years (80.5%) and in this group peak incidence is in 21 -30 years group. The study conducted by Bhatti et al in Northern Pakistan and by Chang et al…”

Section: Discussionsupporting

confidence: 92%

“…in Sindh has shown peak age in the same group and is in accordance with this study. 13,14 The data from UK and USA has shown peak incidence in older age group. 15, 16 Bhatti et al attributed this fact to demographic differences between nations; in the present report, there were greater number of younger subjects and a much smaller number of subjects beyond 60 years.…”

Section: Discussionmentioning

confidence: 99%

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Myelofibrosis in Patients of Chronic Myeloid Leukemia in Chronic Phase at Presentation

Hamid¹,

Ashraf²,

Qamar³

et al. 2019

J Coll Physicians Surg Pak

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Myelofibrosis in Patients of Chronic Myeloid Leukemia in Chronic Phase at Presentation

Hamid¹,

Ashraf²,

Qamar³

et al. 2019

J Coll Physicians Surg Pak

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“…Chang et al also found moderate anemia in 46.9% in CML patients. 15 Hepatomegaly was seen in 45% cases, which was not compareable with study conducted by Khaled et al in Egypt and Chang et al in Aligarh as in them hepatomegaly was seen in 76% and 18% cases respectively. 15,16 In our study majority (63%) of patients presented with normal platelets count and 11% cases with thrombocytopenia and 26% cases with thrombocytosis which is comparable to the study conducted by Sandeep et al which shows 68.9%, 6.7% and 24.4% cases with normal platelet count, thrombocytopenia and thrombocytosis respectively.…”

Section: Discussioncontrasting

confidence: 70%

Study of demographic, hematological profile and risk stratification in chronic myeloid leukemia patients, in and around North-West Punjab, India

et al. 2020

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Background: Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder with cytogenic profile and tyrosine kinase inhibitors used as its therapy. Objective of the present study was to determine the demographic, haematological profile and to characterize them in low and high-risk group on presentation with European treatment and outcome study score (EUTOS) in CML patients in and around North-West Punjab, India.Methods: Diagnosed cases of CML were taken. Investigations were done. Molecular and cytogenetic studies were also done whenever required and with EUTOS patients were stratified and then treatment was individualized.Results: Total 100 patients were enrolled. The mean age of presentation of CML was 44.7 years with M:F ratio was 1:1. 20% cases were of Hindu religion and 80% cases were Sikh by religion. 68% cases from rural area and 32% cases were from urban area. 92 patients were in chronic phase, 5 patients in accelerated phase, and 3 patients were found in blast crisis phase. Out of total 100 cases, 32% cases were of high-risk group and 68% cases were of low-risk group on presentation according to EUTOS.Conclusions: Most CML patients in north west Punjab are young (31-40 years) with male: female ratio is 1:1. Majority of them were Sikh by religion and from rural area. Most of them presented in Chronic phase of the disease and with low-risk strata according to EUTOS. Conclusion is that most patients presents in early phase of disease, with anaemia, leucocytosis or splenomegaly.

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“…Anemia that occurred was mostly in grade 2 (moderate), which was in 45.5% of the sample. This is matched with research conducted in Pakistan, where all patients had anemia, and grade 2 anemia was the most common in 46.9% of patients (Chang et al, 2015).…”

Section: Complete Blood Countssupporting

confidence: 80%

Characteristic of Chronic Myelogenous Leukemia Patients at the Polyclinic of Oncology, Dr. Soetomo General Hospital, Surabaya in 2017

Wiyono

Bintoro

Hernaningsi

2020

MBiom

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Background: Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm because of the reciprocal translocation of chromosome 22 to chromosome 9. In the United States, the incidence of CML is 1.9 cases per 100,000 people. Whereas in Indonesia, there is no specific national data on CML prevalence, especially regarding the clinical picture even though cancer cases reach 1.4 per 1,000 population. Objective: Evaluate the characteristics and clinical features of CML patients in Dr. Soetomo General Hospital, Surabaya. Method: This is a cross-sectional descriptive study with data on the medical records of CML patients in the 2017 period at the Dr. Soetomo General Hospital, Surabaya. The sample in this study was CML patients with positive Breakpoint Clusters Region-Abelson (BCR-ABL), having a minimum age of 18 years and equipped with epidemiological data, complete blood count data, and peripheral blood smear data. Result: Thirty-three patients met the study criteria. The sample was predominantly male, with a ratio of 1.06 : 1 to female patients with a median age of 40 years. Splenomegaly was found in 87.9% of patients. The average results of leukocyte, platelet, and hemoglobin counts were 254.58 x 103 / μL, 557 x 103 / μL, and 9.55 g / dL. From the results of peripheral blood smear obtained normochromic normocytic anisopoikilocytosis erythrocyte (57.6%), all patients had an image of increased leukocytes with blast presence in 97% of patients, and 51.5% had the image of an increase in platelets and the discovery of giant platelets in 33.3% of patients. Conclusion: The sample is predominantly male with the highest incidence at a younger age range of 21-30 years; The clinical characteristics of high leukocytosis with various stage of maturation and a tendency to develop grade 2 normocytic normochromic anemia and thrombocytosis was found in the patients.

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Clinico Hematological Profile and Phase Distribution of Chronic Myeloid Leukemia

Cited by 11 publications

References 0 publications

Myelofibrosis in Patients of Chronic Myeloid Leukemia in Chronic Phase at Presentation

Myelofibrosis in Patients of Chronic Myeloid Leukemia in Chronic Phase at Presentation

Study of demographic, hematological profile and risk stratification in chronic myeloid leukemia patients, in and around North-West Punjab, India

Characteristic of Chronic Myelogenous Leukemia Patients at the Polyclinic of Oncology, Dr. Soetomo General Hospital, Surabaya in 2017

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