Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma

Abstract

BackgroundPrimary gastric adenosquamous carcinoma (ASC) is a rare subset of ASC. This study aims to investigate the clinicopathological features, diagnosis, treatment, and outcomes of primary gastric ASC.MethodsThe medical records of 13 consecutive patients with primary gastric ASC between January 2010 and July 2014 from a single institutional database were reviewed.ResultsMale predominance was observed (M/F = 10/3) among the patients, and their median age was 62 years (range: 43 to 79 years). The primary lesions were most often found in the upper third of the stomach, with a median tumor size of 5 cm (range: 2.25 cm to 10.5 cm). Ten patients underwent radical resections (R0 resection, 76.9%), while three patients had palliative resections (R1/R2 resection, 23.1%). Twelve patients had lymph node metastasis at the time of surgery. Adenocarcinoma and squamous cell carcinoma components in lymph node were found in eight and two cases, respectively, while two patients had both squamous cell carcinoma and adenocarcinoma components. In terms of the TNM staging system, stages IIB, IIIA, IIIB, IIIC, and IV were detected in 2 (15.4%), 2 (15.4%), 1 (7.7%), 5 (38.5%), and 3 (23.1%) patients, respectively. The median follow-up period was 22 months (range: 5 to 52 months); during which, four patients were still alive and eight patients died because of tumor progression. The 1-, 2-, and 3-year survival rates were 76.9%, 46.2%, and 15.4%, respectively.ConclusionsPrimary gastric ASC has a very poor prognosis, and both squamous cell carcinoma and adenocarcinoma components have distant metastasis potential.

Clinicopathological features and prognosis of gastric adenosquamous carcinoma

“…Half of the tumors (52.7%) were stage T4 and the incidence of LNM was 86.2%. These findings were all consistent with previous reports 1, 2, 10 .…”

“…It accounted for less than 1% of all gastric cancers 1 . Gastric ASC is characterized by coexisting of two components (AC and ASC) within the same tumor 2 .…”

Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in aCDKN2Agermline mutation carrier

“…Adenosquamous carcinomas may appear in various locations in the body (gastrointestinal tract[ 6 , 7 ] female reproductive organs[ 8 ], lung, bladder). Adenosquamous pancreatic carcinoma (ASPC) is rare, accounting for less than 5% of all pancreatic carcinomas in the largest series[ 4 ].…”

Primary Gastric Adenosquamous Carcinoma: A Case Report

“…Gastric adenocarcinoma (GAC) is the most common type of stomach cancer, constituting more than 90% of cases [2]. Gastric adenosquamous carcinoma (GASC) is a very rare variant of gastric cancer, accounting for less than 1% of cases [3]. GASC is more aggressive and carries a worse prognosis compared to GAC [4].…”