Cloning, characterization and expression analysis of the gene for a putative lipopolysaccharide-induced TNF-α factor of the Pacific oyster, Crassostrea gigas

The complexity of apoptotic cell death in mollusks: An update

“…Lipopolysaccharide-induced TNF-a factor (LITAF) is one of the most important transcription factors mediating TNF-a transcription. This gene has been identified in several species of bivalve mollusks such as C. farreri, Pinctada fucata, C. gigas, Mizuhopecten yessoensis, Meretrix meretrix and M. edulis [45,66,94,97,144,145].…”

Molecular characterization and expression analysis of a putative LPS-induced TNF-α factor (LITAF) from pearl oyster Pinctada fucata

“…A LITAF signaling pathway was identified in mouse, which was separated from NF-kB and played an important role in regulating of various inflammatory cytokines in response to LPS stimulation [9] Subsequently, several LITAF homologs have been cloned and identified from mouse Mus musculus [10], Gallus gallus chicken [11] and zebrafish Danio rerio [12]. Recently, the LITAF homologs were identified and characterized from pacific oyster Crassostrea gigas and zhikong scallop Chlamys farreri respectively and their expressions in the different tissues and stress conditions have also been investigated [13,14]. However, there are very few LITAF genes isolated and characterized in bivalve molluscs so far, and whether LITAFs function as vertebrate LITAFs in the innate immune responses has been unclear.…”

Genomic organization and promoter analysis of a transcriptional repressor gene from Fenneropenaeus chinensis

“…Several TFs, such as TFs harboring the MYB domain (MYBs) [18,19], Ethylene response factors (ERFs) [20,21], TFs harboring the WRKY domain (WRKYs) [5,22] and basic leucine zipper (bZIPs) [23][24][25] in plants, and Gfil [12], lipopolysaccharide-induced tumor necrosis factor-a (LITAF) [26,27] and E26 transformation-specific (ETS) [28] in animals, have recently been found to play important roles in immune defense responses.…”