“…In pearl production using cultured pearl oysters, a mantle graft and a nucleus are implanted into the gonad of a host pearl oyster; this surgical implantation process can induce the immune response of the host pearl oyster (Li et al, 2010). To elucidate the mechanism of this immune response, various immune-related genes such as LPS-induced tumor necrosis factor-a factor (Zhang et al, 2009a), inhibitor of nuclear factor-kappaB (IkappaB) (Zhang et al, 2009b), inhibitor of nuclear factor-kappaB kinase homolog (Xiong et al, 2008), and F-type lectin (Chen et al, 2011) have been cloned and functionally examined. Although some PAP genes have been identified in mollusks through sequence analysis, the PAP gene has not been characterized in detail and identified in P. martensii.…”