1997
DOI: 10.1038/sj.leu.2400599
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Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle

Abstract: It is well known that loss of tumor suppressor genes and more generally of antiproliferative genes plays a key role in the development of most tumors. We report here the cloning of the mouse BTG3 gene and show that its human counterpart maps on chromosome 21. This evolutionarily conserved gene codes for a 30 kDa protein and is expressed in most adult murine and human tissues analyzed. However, we demonstrate that its expression is cell cycle dependent and peaks at the end of the G1 phase. This gene is homologo… Show more

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Cited by 108 publications
(108 citation statements)
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“…The human BTG2 TIS21/PC3 gene is a member of a newly identified family of six independent antiproliferative genes, namely, BTG1, ANA/BTG3, PC3B, TOB, TOB2 (Rouault et al, 1992;Matsuda et al, 1996;Guehenneux et al, 1997;Yoshida et al, 1998;Ikematsu et al, 1999;Buanne et al, 2000;Tirone, 2001). Although the biological functions of the BTG2 TIS21/PC3 protein remain to be elucidated, several studies have attempted to identify the different cues capable of inducing its expression.…”
Section: Introductionmentioning
confidence: 99%
“…The human BTG2 TIS21/PC3 gene is a member of a newly identified family of six independent antiproliferative genes, namely, BTG1, ANA/BTG3, PC3B, TOB, TOB2 (Rouault et al, 1992;Matsuda et al, 1996;Guehenneux et al, 1997;Yoshida et al, 1998;Ikematsu et al, 1999;Buanne et al, 2000;Tirone, 2001). Although the biological functions of the BTG2 TIS21/PC3 protein remain to be elucidated, several studies have attempted to identify the different cues capable of inducing its expression.…”
Section: Introductionmentioning
confidence: 99%
“…There can be several consequences of the altered gene expression in WS. BTG3 overexpression (Figure 6a) is involved in the negative control of cell cycle progression from the G0/ G1 to S phase (Guehenneux et al, 1997). Thus, WS cells may progress through the cell cycle in spite of persisting DNA damage.…”
Section: Discussionmentioning
confidence: 99%
“…Btg/ Tob genes are a newly characterized family of cell cycle modulators (Guehenneux et al, 1997). Studies in different model systems suggest that they act as antiproliferative genes, they can promote cell differentiation and also regulate apoptosis and cellular senescence (Matsuda et al, 2001;Tirone, 2001;Duriez et al, 2004;Lim, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Studies in different model systems suggest that they act as antiproliferative genes, they can promote cell differentiation and also regulate apoptosis and cellular senescence (Matsuda et al, 2001;Tirone, 2001;Duriez et al, 2004;Lim, 2006). Btg/Tob genes encode for a group of structurally related proteins, characterized by the presence of two novel and highly conserved domains ("antiproliferative" boxes A and B) located in the first 120 residues of the protein (Guehenneux et al, 1997;Guardavaccaro et al, 2000). This gene family is conserved across phylogeny, with two members identified in invertebrates: the gene Fog-3 in C. elegans (Chen et al, 2000) and the mRNA with accession number AF177464 in D. melanogaster.…”
Section: Introductionmentioning
confidence: 99%
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