Clozapine-induced acute interstitial nephritis

Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment

“…A reported case of clozapine-induced acute interstitial nephritis, however, suggests that other internal organs may be involved in reactions to this drug [15].…”

Clozapine-induced interstitial nephritis - a rare but important complication: a case report

“…Acute renal failure has been reported only rarely in association with clozapine therapy [1][2][3][4][5]. Out of a total of over 26,000 suspected adverse reactions to clozapine, the UK Medicines and Healthcare products Regulatory Agency (MHRA) has received only 10 reports of acute interstitial nephritis and 31 reports of acute renal failure (January 2009) [6].…”

“…Out of a total of over 26,000 suspected adverse reactions to clozapine, the UK Medicines and Healthcare products Regulatory Agency (MHRA) has received only 10 reports of acute interstitial nephritis and 31 reports of acute renal failure (January 2009) [6]. In some of the cases [1,4], the diagnosis had been confirmed by biopsy showing that the renal failure had resulted from acute interstitial nephritis. As psychiatrists and other clinicians will appreciate, it is usually not possible to confirm diagnosis by biopsy in most patients with behavioural disturbance due to acute psychosis, despite the recognition that this would normally be clinically desirable.…”

Drugs to treat dementia and psychosis

“…The addition of low-dose clozapine (less than 50 mg/d) is not usually associated with deterioration of PD-related motor symptoms and may improve parkinsonian rest tremor. 29,30 …”