Co-delivery of sorafenib and siVEGF based on mesoporous silica nanoparticles for ASGPR mediated targeted HCC therapy

Zheng, Guirong; Zhao, Rui; Xu, Aixiao; Shen, Zhichun; Chen, Xian; Shao, Jingwei

doi:10.1016/j.ejps.2017.10.036

Cited by 78 publications

(32 citation statements)

References 35 publications

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“…On the other hand, to enhance the uptake of the nanosystems in targeted cells, active targeting strategies have also been employed, using targeting ligands, such as folic acid, antibodies, or lactobionic acid, which have a specific affinity to the receptors overexpressed on the surface of cancer cells [ 11 , 20 , 21 ]. Zhang and colleagues, for instance, designed a nanocarrier based on the active targeting of asialoglycoprotein receptor (ASGPR) using amino-modified MSNs conjugated with lactobionic acid (LA), for the co-delivery of sorafenib and vascular endothelial growth factor (VEGF)-targeted siRNAs (siVEGF) to hepatocellular carcinoma (HCC) [ 49 ]. In this study, the nanocarrier was approximately spherical with an average diameter of 148.5 nm and it was able to enhance the anti-cancer efficacy of sorafenib and siVEGF and significantly inhibited the expression of angiogenesis-related VEGF proteins in Huh7 cells [ 49 ].…”

Section: Silica Nanoparticlesmentioning

confidence: 99%

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications.

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Section: Silica Nanoparticlesmentioning

confidence: 99%

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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“…For SOR the typical adsorption-desorption studies are rarely met in literature (Heidarinasa et al 2016;Zheng et al 2018) thus the mechanism of releasing is not fully understood. In order to shed some light to observed phenomena, i.e.…”

Section: Resultsmentioning

confidence: 99%

New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

et al. 2019

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Metal organic structures have gained recently an interest in many fields. Among them, metal-biomolecule framework materials with amino acids applied as organic linkers have attracted the growing attention. An application of tailored metal-biomolecule frameworks, easily decomposing in an acidic and/or reductive environment in a steerable way, is reported here. From these biocompatible, non-porous, and nanostructured drug carrier systems, the desirable portion of drug could be released depending on the portion of acid, i.e. immediately and/or in a multi-step process due to a structure decomposition. The application of naturally occurring elements as cystine ensures full biocompatibility of the obtained system as well as its degradation products. Presented materials offer potential application in drug delivery systems.

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“…Mesoporous silicon-based NMs are composed of amorphous skeletons with a high pore capacity, are uniform with an adjustable pore size, and have an available functionalization and interface effect [40]. Furthermore, this kind of material has good biocompatibility, contributing to its wide application prospects in fields of biotechnology such as drug delivery [41] and gene therapy [42,43]. The discovery of MSNs has greatly promoted the development of sustained and controlled drug release field.…”

Section: Mesoporous Silica Nms (Msns)mentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Co-delivery of sorafenib and siVEGF based on mesoporous silica nanoparticles for ASGPR mediated targeted HCC therapy

Cited by 78 publications

References 35 publications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

New strategy of controlled, stepwise release from novel MBioF and its potential application for drug delivery systems

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

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