Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet

Matsuda, Yuji; Kobayashi, Misato; Yamauchi, Rie; Ojika, Makoto; Hiramitsu, Masanori; Inoue, Takashi; Katagiri, Takao; Murai, Atsushi; Horio, Fumihiko

doi:10.1271/bbb.110452

Cited by 54 publications

(40 citation statements)

References 41 publications

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“…Control: n512 (saline: n55; insulin: n57); Coffee: n512 (saline: n55; insulin: n57). enhanced insulin sensitivity in both diabetic KK-A y mice and C57BL/6J mice fed a high-fat diet (4,5), both of which develop insulin resistance in peripheral tissues. However, the mechanisms underlying the improvement of insulin sensitivity by coffee ingestion remained to be clarified in these diabetic models.…”

Section: Discussionmentioning

confidence: 99%

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Kobayashi

Matsuda

Iwai

et al. 2012

J Nutr Sci Vitaminol

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Section: Discussionmentioning

confidence: 99%

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Kobayashi

Matsuda

Iwai

et al. 2012

J Nutr Sci Vitaminol

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“…14 Third, caffeine can activate Akt phosphorylation. 11,12,14 Fourth, caffeine intake did not affect circulating insulin secretion significantly. 40 Finally, caffeine does not alter the phosphorylation of the insulin receptor, IRS1-associated PI3K, or Akt S473 .…”

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confidence: 82%

“…Epidemiological studies have shown that long-term caffeine consumption diminishes diabetic symptoms by enhancing insulin sensitivity through more efficient insulin signaling. 11,12 However, although some studies have shown that acute caffeine consumption elevates BP, other studies have shown that habitual coffee intake is less likely to increase BP. 13,14 In fact, current studies have suggested a protective role of coffee intake against hypertension.…”

Section: S307mentioning

confidence: 99%

Caffeine Intake Improves Fructose-Induced Hypertension and Insulin Resistance by Enhancing Central Insulin Signaling

et al. 2014

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535I n humans, the intake of sugar-sweetened beverages is correlated with the prevalence of type 2 diabetes mellitus and obesity.1 High fructose intake is used as a well-established animal model for insulin resistance.2 Some studies have shown that chronic fructose intake in normal rats induces hypertension in association with insulin resistance.2,3 However, insulin infusion was found to stimulate local vasodilation by enhancing the action of nitric oxide (NO). 4 The effect of insulin on the baroreceptor reflex in nucleus tractus solitarii (NTS) is probably mediated by a change in sympathetic nervous activity. 4,5 Furthermore, sympathectomy can prevent the development of fructose-induced hypertension in rats. 6 Recent studies suggest that fructose consumption increases superoxide generation and attenuates baroreflex response. 7,8 Interestingly, inhibition of superoxide generation in NTS can reduce blood pressure (BP) in stroke-prone hypertensive rats. 9 The NTS is located in the dorsal medulla of the brain stem, which is the primary integrating center for cardiovascular regulation and other autonomic functions of the central nervous system. Furthermore, NO has important modulatory functions in the NTS, including the modulation of arterial BP and sympathetic nerve activity. 10 In previous experiments, we demonstrated that insulin microinjected into the NTS induces a depressor effect and initiates an interaction between insulin and phosphatidylinositol 3-kinase Abstract-Recent clinical studies found that fructose intake leads to insulin resistance and hypertension. Fructose consumption promotes protein fructosylation and formation of superoxide. In a previous study, we revealed that inhibition of superoxide production in the nucleus tractus solitarii (NTS) reduces blood pressure. Caffeine displays significant antioxidant ability in protecting membranes against oxidative damage and can lower the risk of insulin resistance. However, the mechanism through which caffeine improves fructose-induced insulin resistance is unclear. The aim of this study was to investigate whether caffeine consumption can abolish superoxide generation to enhance insulin signaling in the NTS, thereby reducing blood pressure in rats with fructose-induced hypertension. Treatment with caffeine for 4 weeks decreased blood pressure, serum fasting glucose, insulin, homeostatic model assessment-insulin resistance, and triglyceride levels and increased the serum direct high-density lipoprotein level in fructose-fed rats but not in control rats. Caffeine treatment resulted in the recovery of fructose-induced decrease in nitric oxide production in the NTS. Immunoblotting and immunofluorescence analyses further showed that caffeine reduced the fructoseinduced phosphorylation of insulin receptor substrate 1 (IRS1 S307) and reversed Akt S473 and neuronal nitric oxide synthase phosphorylation. Similarly, caffeine was able to improve insulin sensitivity and decrease insulin levels in the NTS evoked by fructose. Caffeine intake also reduced the production o...

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“…In KK-A y mice, which spontaneously develop type 2 diabetes, coffee ingestion suppressed hyperglycemia, hyperinsulinemia, hyperlipidemia, and hepatic steatosis (3). In C57BL/6J mice fed a high-fat diet, coffee ingestion also improved insulin sensitivity (4). Furthermore, we found that coffee increased the activation of Akt in insulin signaling in the liver and skeletal muscle (5).…”

mentioning

confidence: 62%

“…Previously we reported that coffee had an anti-diabetic effect in both spontaneous and diet-induced type 2 diabetes in animal models (3,4). In KK-A y mice, which spontaneously develop type 2 diabetes, coffee ingestion suppressed hyperglycemia, hyperinsulinemia, hyperlipidemia, and hepatic steatosis (3).…”

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confidence: 96%

Coffee Ingestion Suppresses Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Kobayashi

Kurata

Hamana

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Coffee consumption reduces the risk of type 2 diabetes in humans, but the mechanism remains unclear. In this study, we investigated the effect of coffee on pancreatic b-cells in the induction of diabetes by streptozotocin (STZ) treatment in mice. We examined the effect of coffee, caffeine, or decaffeinated coffee ingestion on STZ-induced hyperglycemia. After STZ injection in Exp. 1 and 2, serum glucose concentration and water intake in coffee ingestion (Coffee group) tended to be lowered or was significantly lowered compared to those in water ingestion (Water group) instead of coffee. In Exp. 1, the values for water intake and serum glucose concentration in caffeine ingestion (Caffeine group) were similar to those in the Water group. In Exp. 2, serum glucose concentrations in the decaffeinated coffee ingestion (Decaf group) tended to be lower than those in the Water group. Pancreatic insulin contents tended to be higher in the Coffee and Decaf groups than in the Water group (Exp. 1 and 2). In Exp. 3, subsequently, we showed that coffee ingestion also suppressed the deterioration of hyperglycemia in diabetic mice which had been already injected with STZ. This study showed that coffee ingestion prevented the development of STZ-induced diabetes and suppressed hyperglycemia in STZ-diabetic mice. Caffeine or decaffeinated coffee ingestion did not significantly suppress STZ-induced hyperglycemia. These results suggest that the combination of caffeine and other components of decaffeinated coffee are needed for the preventive effect on pancreatic b-cell destruction. Coffee ingestion may contribute to the maintenance of pancreatic insulin contents. Key Words streptozotocin, diabetes, hyperglycemia, coffee, caffeine In 2015, 415 million people worldwide were estimated to be affected by type 2 diabetes (1). The International Diabetes Federation estimates that this will rise to 642 million individuals by the year 2040, and warns that the prevalence of type 2 diabetes will increase. These increases are caused by changes in environmental factors such as quantity and quality of food and exercise, and therefore modification of environmental factors can contribute to the prevention of type 2 diabetes.In humans, many studies have revealed an association between coffee consumption and decreased risk of type 2 diabetes. A meta-analysis of 28 studies published between 1966 and 2013 showed that daily consumption of six cups of coffee was associated with a 33% lower risk of diabetes, and that coffee consumption dose-dependently reduced the risk of type 2 diabetes (2). In addition, the reduction in type 2 diabetes risk was observed with both, caffeinated and decaffeinated coffee. However, the mechanism of the anti-diabetic effect of coffee remains unclear.Previously we reported that coffee had an anti-diabetic effect in both spontaneous and diet-induced type 2 diabetes in animal models (3, 4). In KK-A y mice, which spontaneously develop type 2 diabetes, coffee ingestion suppressed hyperglycemia, hyperinsulinemia, hyperlipidemia...

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Coffee and Caffeine Improve Insulin Sensitivity and Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet

Cited by 54 publications

References 41 publications

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Coffee Improves Insulin-Stimulated Akt Phosphorylation in Liver and Skeletal Muscle in Diabetic KK-Ay Mice

Caffeine Intake Improves Fructose-Induced Hypertension and Insulin Resistance by Enhancing Central Insulin Signaling

Coffee Ingestion Suppresses Hyperglycemia in Streptozotocin-Induced Diabetic Mice

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