Coffee Consumption Could Affect the Activity of Some Liver Enzymes and Other Biochemical Parameters in Healthy Drinkers

Onuegbu, Anaelechi J.; Olisekodiaka, Japhet M.; Adebolu, Olubukunmi E.; Adesiyan, Adekunle A.; Ayodele, Olugbenga Edward

doi:10.1159/000328420

Cited by 12 publications

(10 citation statements)

References 41 publications

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“…Our findings confirmed previous studies [7,8,10,16,17] that revealed an alteration of lipid metabolism in advanced stages of viral liver cirrhosis principally because hepatocyte alteration was already profound. Patients were preselected in advanced disease stages, thus hepatocyte alteration was already profound.…”

Section: Discussionsupporting

confidence: 92%

Lipid Serum Profile in Patients with Viral Liver Cirrhosis

Vere

Streba

et al. 2012

Med Princ Pract

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Objective: Our main aim was to investigate the serum lipid levels in a series of patients with liver cirrhosis of viral origin. Subjects and Methods: The study comprised 90 patients, 60 with viral liver cirrhosis, equally divided between hepatitis virus C (HCV) and B (HBV) etiologies, and 30 control patients with no known liver pathology. Patients were investigated during a 5-year period in the 1st Medical Clinic of the Emergency County Hospital of Craiova, Romania. The following series of serum lipid parameters were recorded: lipemia, total cholesterol and cholesteryl ester, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol and triglyceride (TG) values. Statistical analysis of these parameters was performed using the ANOVA test followed by Tukey multiple comparison teststo compare replicate means; p < 0.05 was considered statistically significant. Results: We observed significantly lower values for serum lipids (543.5 and 549.37 mg/dl in the HBV and HCV cirrhosis subgroups, compared with 649.9 mg/dl in controls), total cholesterol (143.6 and 147.9 vs. 198.0 mg/dl, respectively), cholesteryl esters (83.6 and 80, compared to 147.9 mg/dl, respectively), LDL cholesterol (91.6 and 88.5 vs. 132.4 mg/dl) in both cirrhosis groups when compared with controls (p < 0.001), as well as HDL cholesterol (32.1 and 36.9 vs. 47.3 mg/dl, p < 0.05). However, TG and VLDL cholesterol values of controls and cirrhosis groups were similar (p > 0.05). We did not register any differences between the two cirrhosis groups (p > 0.05). Conclusion: Our data showed that both HCV and HBV cirrhosis severely impaired liver lipid metabolism. Late stages of the disease resulted in a pseudonormalization of VLDL cholesterol and TG values.

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Section: Discussionsupporting

confidence: 92%

Lipid Serum Profile in Patients with Viral Liver Cirrhosis

Vere

Streba

et al. 2012

Med Princ Pract

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“…Apart from the total bilirubin level of group I (50 mg/kg BW), bilirubin levels for other test groups (both total and conjugated) were significantly ( < 0.05) reduced when compared to the control in this study (Figures 4 and 5). However, since the levels were within bilirubin acceptable range of 0.2-1.2 mg/dl, the observed decrease is too small and could not be linked with cholestatic disease [41]. The observed decrease in bilirubin levels in the present study agree with the earlier work of Aloy-Amadi et al, [42] who reported a decrease in bilirubin levels following intake of strong unfiltered coffee.…”

Section: Resultssupporting

confidence: 77%

Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

Agomuo

Majesty

Augustine

et al. 2017

Advances in Biology

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Effect of caffeine on some selected biochemical parameters using rat model was investigated. Standard methods of analysis were used for the study. A total of sixty (60) rats divided equally into five groups of which one group served as the control, and the rest as test groups were used. The test rats were placed on different concentrations of caffeine for twenty-eight (28) days. Results obtained for the selected biochemical parameters revealed that AST and ALT levels of the liver increased significantly ( < 0.05) in test rats against the control. Creatinine and electrolyte ions of the kidney increased significantly ( < 0.05) in test groups when compared to the control. Haematological indices such as WBC, monocytes, lymphocytes, MCV, MCHC, and MCV levels were significantly altered ( < 0.05) in test rats against those of the control. It therefore becomes imperative for those that consume caffeine with believe that it does more good work than harm to take note of these findings. This study has revealed the effect of caffeine on some selected biochemical parameters using rat model.

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“…Significant differences in AST and ALT were reported in a National Toxicology Program study in Fischer 244 rats on caffeine at doses up to 287 mg/kg bw/day; however, no dose-related patterns were established [33]. Slight but significant increases in AST and ALT have also been reported in humans with consumption of coffee [34], although coffee/caffeine consumption has also been associated with protective effects against increases in liver enzymes (e.g., ALT) and liver protection in general [35–37]. Caffeine (and likely theacrine) is metabolized in the liver [33, 38] and thus high doses could theoretically have an effect on this organ due to high exposure chronically.…”

Section: Resultsmentioning

confidence: 99%

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Clewell

Hirka²,

Glávits³

et al. 2016

Journal of Toxicology

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A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals.

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Coffee Consumption Could Affect the Activity of Some Liver Enzymes and Other Biochemical Parameters in Healthy Drinkers

Cited by 12 publications

References 41 publications

Lipid Serum Profile in Patients with Viral Liver Cirrhosis

Lipid Serum Profile in Patients with Viral Liver Cirrhosis

Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

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