Collagen modified with epoxidized safrole for improving antibacterial activity

Xu, Zhaoyi; Chang, Jinming; Zhang, Peikun; Guan, Xiaoyu; Chen, Yi; Fan, Haojun

doi:10.1039/c7ra08319j

Cited by 13 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the incorporation of an antibacterial effect in Col further contributes to its physicochemical characteristics. Col can be integrated with silver nanoparticles (AgNP) [ 63 ], collagencin [ 64 ], epoxidized safrole [ 65 ], polyhexamethylene biguanide [ 66 ], titanium dioxide [ 67 ], etc. Similarly, native gelatin does not show any antibacterial effect.…”

Section: Differences Between Collagen and Gelatinmentioning

confidence: 99%

Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review

et al. 2021

View full text Add to dashboard Cite

Collagen (Col) and gelatin are most extensively used in various fields, particularly in pharmaceuticals and therapeutics. Numerous researchers have proven that they are highly biocompatible to human tissues, exhibit low antigenicity and are easy to degrade. Despite their different sources both Col and gelatin have almost the same effects when it comes to wound healing mechanisms. Considering this, the bioactivity and biological effects of both Col and gelatin have been, and are being, constantly investigated through in vitro and in vivo assays to obtain maximum outcomes in the future. With regard to their proven nutritional values as sources of protein, Col and gelatin products exert various possible biological activities on cells in the extracellular matrix (ECM). In addition, a vast number of novel Col and gelatin applications have been discovered. This review compared Col and gelatin in terms of their structures, sources of derivatives, physicochemical properties, results of in vitro and in vivo studies, their roles in wound healing and the current challenges in wound healing. Thus, this review provides the current insights and the latest discoveries on both Col and gelatin in their wound healing mechanisms.

show abstract

Section: Differences Between Collagen and Gelatinmentioning

confidence: 99%

Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, increased mechanical and thermal collagen-properties without functionality loss were reported. Therefore, OYBD showed strong potential as a novel modifier for the development of antibacterial collagen-based biomaterials [ 252 ]. Apart from that, isolated safrole from Ocotea odorifera EO was recently found to possess remarkable antibacterial and antibiotic-modulating properties against multi-resistant efflux pump (EP)-carrying strains.…”

Section: Essential Oils From Selected Rootsmentioning

confidence: 99%

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

View full text Add to dashboard Cite

Since ancient times, plant roots have been widely used in traditional medicine for treating various ailments and diseases due to their beneficial effects. A large number of studies have demonstrated that—besides their aromatic properties—their biological activity can often be attributed to volatile constituents. This review provides a comprehensive overview of investigations into the chemical composition of essential oils and volatile components obtained from selected aromatic roots, including Angelica archangelica, Armoracia rusticana, Carlina sp., Chrysopogon zizanioides, Coleus forskohlii, Inula helenium, Sassafras albidum, Saussurea costus, and Valeriana officinalis. Additionally, their most important associated biological impacts are reported, such as anticarcinogenic, antimicrobial, antioxidant, pesticidal, and other miscellaneous properties. Various literature and electronic databases—including PubMed, ScienceDirect, Springer, Scopus, Google Scholar, and Wiley—were screened and data was obtained accordingly. The results indicate the promising properties of root-essential oils and their potential as a source for natural biologically active products for flavor, pharmaceutical, agricultural, and fragrance industries. However, more research is required to further establish the mechanism of action mediating these bioactivities as well as essential oil standardization because the chemical composition often strongly varies depending on external factors.

show abstract

“…Additionally, DDSA‐collagen gels showed antibacterial properties mainly against Gram‐positive bacteria due to the increased hydrophobicity which is believed to be favorable in preventing water and bacteria intrusion for collagen‐based biomaterials (Xu et al, ). It has also been demonstrated that pathogenic bacteria and fungi have hydrophobic characteristics that make them irreversibly bind strongly to hydrophobic wound dressings by a physical principle (Ljungh, Yanagisawa, & Wadström, ).…”

Section: Discussionmentioning

confidence: 99%

Dodecenylsuccinic anhydride modified collagen hydrogels loaded with simvastatin as skin wound dressings

Olivetti

Echazú

Perna

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

Skin wound healing presents a unique challenge because of its complex healing process. Herein, we developed a hydrophobic wound dressing to incorporate simvastatin, which has potential application in the treatment of ulcers and prevention of wound infection. For that matter, collagen hydrogels were grafted with dodecenylsuccinic anhydride (DDSA). The chemical modification was confirmed by FTIR and solid state 13C‐NMR spectroscopies while the ultrastructure was observed by scanning electron microscope (SEM) images. In contact angle measurements, a higher water droplet angle in DDSA‐collagen gels was observed. This was consistent with the swelling assay, in which water absorption was 5.2 g/g for collagen and 1.9 g/g for DDSA‐collagen. Additionally, viability and adhesion studies were performed. Cell adhesion decreased ~11% in DDSA‐collagen and the number of viable cells showed a tendency to decrease as DDSA concentration increased but it was only significantly lower above concentrations of 12%. Modified gels were loaded with simvastatin showing higher adsorption capacity and lower release. Lastly, the antimicrobial and anti‐inflammatory activity of DDSA‐collagen materials were assessed. DDSA‐collagen hydrogels, either unloaded or loaded with simvastatin showed sustained antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus for 72 hr probably due to the hydrophobic interaction of DDSA chains with bacterial cell walls. The antimicrobial activity was stronger against S. aureus. Collagen hydrogels also presented a prolonged antibacterial activity when they were loaded with simvastatin, confirming the antimicrobial properties of statins. Finally, it was observed that these materials can stimulate resident macrophages and promote an M2 profile which is desirable in wound healing processes.

show abstract

Collagen modified with epoxidized safrole for improving antibacterial activity

Cited by 13 publications

References 25 publications

Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review

Natural-Based Biomaterial for Skin Wound Healing (Gelatin vs. Collagen): Expert Review

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Dodecenylsuccinic anhydride modified collagen hydrogels loaded with simvastatin as skin wound dressings

Contact Info

Product

Resources

About