Colorectal carcinoma in patients less than 40 years of age

Abstract

The mean incidence of colorectal carcinoma in persons under age 40 in Sweden is 1.74/100,000/year. Over a 30-year period, 1950 through 1979, 1061 patients with colorectal carcinoma were seen, 48 of whom where under age 40 (21 to 39 years) and in this study were compared with older patients. Carcinoma was superimposed upon ulcerative colitis in 18 patients. All patients treated for palliation died within two years. Curability rate. 67 per cent, and the proportion of Dukes' A lesions were the same as in older patients, whereas young patients had fewer B and more C lesions. Five-year survival was 33 per cent overall and 50 per cent in curable cases, not different from the rates in older patients (33 and 47 per cent). Five-year survival was 100 per cent in stage A, 50 per cent in stage B, and 33 per cent in stage C. The age factor had no impact upon survival, and colitic origin of a carcinoma did not decrease survival more than did carcinoma itself. It is concluded that colorectal carcinoma in patients under age 40 differs in no respect from the disease in older patients.

Systematic evaluation of surgical strategies for acute malignant left-sided colonic obstruction

“…Those who favour primary resection argue that the overall mortality is similar to that of other strategies, and simultaneous treatment of the carcinoma and the obstruction benefits longterm outcome 48 -50 . Others disagree, demonstrating better results for staged procedures 2,46,51 .…”

Rectal Cancer in the Young Patient

“…Other studies contradict these findings. [22][23][24][25][26][27][28][29][30][31][32][33][34][35] Most of these studies are single-institution series, and to our knowledge, no national population-based study, focusing on rectal cancer in the young after the introduction of the TME technique, has been published.…”

Evolução do carcinoma colorretal, comparando doentes com idades acima e abaixo de 40 anos, quanto à diferenciação tumoral e ao estádio do tumor

“…[8][9][10][11][12] Alguns estudos têm demonstrado que doentes mais jovens apresentam prognóstico pior, com sobrevivência menor comparativamente aos mais idosos, [13][14][15] fato não observado por outros. 16,17 Todavia, os fatores para esse pior prognóstico seriam o estádio mais avançado da doença ao diagnóstico 18,19 e a presença de tumores menos diferenciados.…”

“…20 Quando se compararam os estádios da doença em indivíduos mais jovens e mais velhos que 40 anos, afirmaram que nos mais jovens a doença apresentouse em estádio mais avançado. [8][9][10][11]15 Todavia, outros estudos não observaram essa diferença.…”