Colorimetric microneedle patches for multiplexed transdermal detection of metabolites

Zhu, Dan; Zheng, Le Wen; Duong, Phan Khanh; Cheah, Reanne Hui; Liu, Xin Yi; Wong, Jun Ren; Wang, Wen Jun; Guan, Steven Thng Tien; Zheng, Xin; Chen, Peng

doi:10.1016/j.bios.2022.114412

Cited by 65 publications

(35 citation statements)

References 28 publications

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“…The relative error values are greater when LOx/γ-/α-Fe 2 O 3 was used compared to those values obtained with LOx/γ-/α-Fe 2 O 3 /ZnO. Finally, the obtained values of lactate concentration obtained by using the NPs synthesized in this work are comparable with those previously obtained by other authors in body fluids such as sweat [ 52 , 53 ] and blood [ 49 , 54 , 55 ]. A better fit in the linearity of the lactate sensor is important because it reduces measurement errors and is easier to calibrate.…”

Section: Resultssupporting

confidence: 84%

Comparative Colorimetric Sensor Based on Bi-Phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO Nanoparticles for Lactate Detection

et al. 2022

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This work reports on Fe2O3 and ZnO materials for lactate quantification. In the synthesis, the bi-phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO nanoparticles (NPs) were obtained for their application in a lactate colorimetric sensor. The crystalline phases of the NPs were analyzed by XRD and XPS techniques. S/TEM images showed spheres with an 18 nm average and a needle length from 125 to 330 nm and 18 nm in diameter. The γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO were used to evaluate the catalytic activity of peroxidase with the substrate 3,3,5,5-tetramethylbenzidine (TMB), obtaining a linear range of 50 to 1000 μM for both NPs, and a 4.3 μM and 9.4 μM limit of detection (LOD), respectively. Moreover, γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO/lactate oxidase with TMB assays in the presence of lactate showed a linear range of 50 to 1000 µM, and both NPs proved to be highly selective in the presence of interferents. Finally, a sample of human serum was also tested, and the results were compared with a commercial lactometer. The use of ZnO with Fe2O3 achieved a greater response toward lactate oxidation reaction, and has implementation in a lactate colorimetric sensor using materials that are economically accessible and easy to synthesize.

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Section: Resultssupporting

confidence: 84%

Comparative Colorimetric Sensor Based on Bi-Phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO Nanoparticles for Lactate Detection

et al. 2022

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“…113,132 In general, colorimetric signals are induced by changes in chemical structures, densities, orientations, morphologies, or sizes of chromogenic agents upon interaction with the target substance. 133 Based on different principles of color development, the chromogenic agents could be classified as redox-responsive agents, 120,125,130,134 and nanostructures. 121,135…”

Section: Integrated Microneedle Sensing Systemsmentioning

confidence: 99%

“…125 Similarly, Zeng et al designed paper sensor-integrated microneedles for multi-metabolite analysis in ISF. 134 Moreover, direct addition of chromogenic agents into microneedles enables fully integrated sensor fabrication. 120,121,131,132 Wang et al applied GO x , horseradish peroxidase (HRP), and 3,3′,5,5′-tetramethylbenzidine (TMB) into PVA layers to realize the in situ colorimetric detection of glucose in a type 1 diabetic mouse model.…”

Section: Integrated Microneedle Sensing Systemsmentioning

confidence: 99%

Microneedle-based transdermal detection and sensing devices

Wang

Cai

et al. 2023

Lab Chip

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“…Dissolvable MN patches are generally made of natural polysaccharides, such as hyaluronic acid (HA) [43], dextran [44], and chitosan [45], or water-soluble polymers, such as polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) [46]. Dissolvable MN patches have good solubility and can dissolve rapidly after contacting interstitial fluid (ISF) in the skin [47,48], thereby achieving transdermal delivery of different types of drugs, including contraceptives (Figure 1). For example, Yao et al [37] added chitosan and beta-sodium glycerophosphate (β-GP) in the formulation of MNs, which significantly accelerated the dissolution of MNs after skin insertion.…”

Section: Dissolvable Mn Patches For Sustained Release Of Hormonesmentioning

confidence: 99%

Advances in microneedle patches for long-acting contraception

Jiang

Zeng

Zhang

et al. 2023

Acta Materia Medica

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Despite the advances in contraceptives, there is still a high rate of unintended pregnancies worldwide, due in large part to the lack of effective, convenient, and safe birth control methods. Compared with short-acting contraceptives, approaches that offer long-term pregnancy protection have attracted greater interest because of the reduced dosing frequency and improved patient compliance. As a novel transdermal drug delivery system, the microneedle (MN) patch has been widely used for a variety of biomedical applications, including long-acting contraception, due to unique properties, such as painless self-administration and elimination of biohazardous waste. In this review we provide a systemic review of MN patches that have been utilized for long-term contraception, including dissolvable MN patches, polymeric biodegradable MN patches, and silk fibroin-based biodegradable MN patches. The acceptability and biosafety of these contraceptive MN patches are also discussed. Finally, we give our perspectives on the future clinical translation of MN patches for long-acting contraception.

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Colorimetric microneedle patches for multiplexed transdermal detection of metabolites

Cited by 65 publications

References 28 publications

Comparative Colorimetric Sensor Based on Bi-Phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO Nanoparticles for Lactate Detection

Comparative Colorimetric Sensor Based on Bi-Phase γ-/α-Fe2O3 and γ-/α-Fe2O3/ZnO Nanoparticles for Lactate Detection

Microneedle-based transdermal detection and sensing devices

Advances in microneedle patches for long-acting contraception

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