Combination treatment with photodynamic therapy and laser therapy in chronic hyperplastic candidiasis: A case report

Zhang, Wenqing; Wu, Shuangshuang; Wang, Xu; Pan, Wei; Zhang, Yan

doi:10.1016/j.pdpdt.2022.102819

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…37 The prior studies reported that laser therapy can be used as both adjuvant treatment or alternative treatment for treating oral candidiasis, which is resistant to antifungal therapy, particularly in immunocompromised patients. [39][40][41][42] This study has some limitations, including the availability of laser types with different parameters, which are also related to laser exposure time, and the fact that advanced tests were not carried out for mutation patterns. In addition, this study also requires a larger sample size because it uses several clinical parameters.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer

Hasanah,

Sufiawati,

Kusumadjati

et al. 2024

J Lasers Med Sci

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Introduction: Studies on head and neck cancer (HNC) patients undergoing radiotherapy have revealed increased numbers of Candida spp., leading to oral candidiasis and oral mucositis. The effects of laser therapy on Candida spp. have been studied with varied results. This study aimed to investigate the effect of low-level laser therapy (LLLT) on C. albicans colonies isolated from HNC patients undergoing radiotherapy. Methods: This study included a treated group, wherein 11 C. albicans isolates were obtained from the saliva of HNC patients undergoing radiotherapy at a dose exceeding 30 Gy. The control groups consisted of an untreated negative control and a positive control treated with nystatin. The treatment groups were subjected to LLLT in continuous mode for 50 seconds at a wavelength of 976 nm, 0.1 W at a dose of 5 J/cm2 for Laser 1 (L1) group and 0.2 W at a dose of 10 J/cm2 for Laser 2 (L2) group. The tests were conducted using C. albicans inoculum equivalent to a 0.5-McFarland suspension on 96-well plates. All test group inoculums were then cultured on Sabouraud dextrose agar (SDA), and the colony count was assessed at 104 CFU/mL. Results: LLLT at 5 and 10 J/ cm2 reduced C. albicans colonies by 7.01% and 10.94%, respectively, but the reductions were not statistically significant (P>0.05). Nystatin eliminated all the colonies. Conclusion: LLLT shows potential for reducing C. albicans colonies in HNC patients undergoing radiotherapy. However, further studies with varied parameters and methods are necessary.

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Section: Discussionmentioning

confidence: 99%

In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer

Hasanah,

Sufiawati,

Kusumadjati

et al. 2024

J Lasers Med Sci

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“…Chronic hyperplastic candidosis (CHC) is a chronic disorder of the oral mucosa [1][2][3]. Chronic oral lesions with a higher incidence include oral potentially malignant disorders (OPMDs), ulcerations of different etiology, chronic candidiasis, and the manifestation of autoimmune bullous diseases [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Increased susceptibility is manifested through immunosuppression, comprising HIV infection and immunosuppressive medication usage. Other risk factors include insufficient oral hygiene, smoking, overindulgence in alcohol, and prosthetic devices in the mouth [1][2][3]. Also, some systematic conditions, like diabetes mellitus, can cause a person to be more susceptible to CHC.…”

Section: Introductionmentioning

confidence: 99%

Predicting Chronic Hyperplastic Candidiasis Retro-Angular Mucosa Using Machine Learning

Moztarzadeh,

Liska,

Liskova

et al. 2023

Clinics and Practice

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Chronic hyperplastic candidiasis (CHC) presents a distinctive and relatively rare form of oral candidal infection characterized by the presence of white or white–red patches on the oral mucosa. Often mistaken for leukoplakia or erythroleukoplakia due to their appearance, these lesions display nonhomogeneous textures featuring combinations of white and red hyperplastic or nodular surfaces. Predominant locations for such lesions include the tongue, retro-angular mucosa, and buccal mucosa. This paper aims to investigate the potential influence of specific anatomical locations, retro-angular mucosa, on the development and occurrence of CHC. By examining the relationship between risk factors, we present an approach based on machine learning (ML) to predict the location of CHC occurrence. In this way, we employ Gradient Boosting Regression (GBR) to classify CHC lesion locations based on important risk factors. This estimator can serve both research and diagnostic purposes effectively. The findings underscore that the proposed ML technique can be used to predict the occurrence of CHC in retro-angular mucosa compared to other locations. The results also show a high rate of accuracy in predicting lesion locations. Performance assessment relies on Mean Squared Error (MSE), Root Mean Squared Error (RMSE), R-squared (R2), and Mean Absolute Error (MAE), consistently revealing favorable results that underscore the robustness and dependability of our classification method. Our research contributes valuable insights to the field, enhancing diagnostic accuracy and informing treatment strategies.

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Clinical efficacy of 5-aminolevulinic acid-mediated photodynamic therapy versus topical antifungal agent and surgical excision for the treatment of hyperplastic candidiasis

AlGhamdi

Qamar

AlSheikh

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Combination treatment with photodynamic therapy and laser therapy in chronic hyperplastic candidiasis: A case report

Cited by 6 publications

References 6 publications

In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer

In Vitro Effect of Low-level Laser Therapy on Candida albicans Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer

Predicting Chronic Hyperplastic Candidiasis Retro-Angular Mucosa Using Machine Learning

Clinical efficacy of 5-aminolevulinic acid-mediated photodynamic therapy versus topical antifungal agent and surgical excision for the treatment of hyperplastic candidiasis

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