Comparative efficacy of narrow-band ultraviolet B phototherapy alone and its combination with topical 8-methoxypsoralen in psoriasis

Abstract

To conclude, topical 8-MOP enhances the therapeutic effects of NBUVB therapy without increasing the incidence of adverse effects.

Comparison of topical 8‐methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment‐resistant sites in plaque‐type psoriasis: a placebo‐controlled study

“…Recently, Jain et al . compared the combination of psoralen‐NBUVB with NBUVB alone in psoriasis; the number of treatment sessions and cumulative doses were lower with the combination therapy, although not to a significant level .…”

“…They showed 58.6% decrease in total score after nine sessions in contrast to 37.7% in the control group (P = 0.043).They concluded that combination of 8MOP with NBUVB increased the rate of improvement in treatment-resistant lesions of psoriasis (7). Recently, Jain et al compared the combination of psoralen-NBUVB with NBUVB alone in psoriasis; the number of treatment sessions and cumulative doses were lower with the combination therapy, although not to a significant level (8).…”

“…Several studies have shown that topical PUVA is especially effective in localized forms of psoriasis. The combination of psoralen and NBUVB is less well established, and studies about this combination are limited . The mechanism of action of psoralen plus NBUVB has not been elucidated for certain, but direct effect of NBUVB together with psoralen photoproduct may be the cause .…”

“…Besides its well‐known role in PUVA therapy, oral psoralen has been shown to increase the efficacy of NBUVB . Topical psoralen, too, was proven to be effective in a few studies in combination with NBUVB . Topical psoralen NBUVB may have the advantage of treating selected lesions without systemic psoralen toxicity.…”

Fototerapia en combinación con otras terapias en psoriasis

“…Sin embargo, no hay datos clínicos sobre el desarrollo de carcinogénesis en humanos. Por lo anterior, se recomienda el uso prudente en casos de psoriasis [5][6][7][8][9][10][11][12][13][14][15][16] .…”