2013
DOI: 10.1016/j.freeradbiomed.2013.10.007
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Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

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Cited by 41 publications
(37 citation statements)
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“…This is not a comparable exposure method to those with intact cells, which can regulate both accessibility of different subcellular compartments to chemicals as well as dynamic responses after exposure. Furthermore, HOSCN is well "sensed" by cell signaling pathways (44,45), and only slowly permeates whole cells (46). This could greatly influence resulting SERCA activity in intact cells compared with isolated SR vesicles.…”
Section: Discussionmentioning
confidence: 99%
“…This is not a comparable exposure method to those with intact cells, which can regulate both accessibility of different subcellular compartments to chemicals as well as dynamic responses after exposure. Furthermore, HOSCN is well "sensed" by cell signaling pathways (44,45), and only slowly permeates whole cells (46). This could greatly influence resulting SERCA activity in intact cells compared with isolated SR vesicles.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanisms underlying acute inflammation-induced body injury primarily involve damage to the vascular endothelial cells by cellular contents, such as O 2 - and MPO released from neutrophils, and increased leukocyte adhesion to vascular endothelial and epithelial cells (cascade amplification), which is induced by the upregulated expression of various cytokines [11,12]. Therefore, inhibiting the release of cellular contents from neutrophils and reducing leukocyte adhesion to endothelial cells have become the key strategies for the treatment of acute inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…Although many findings in whole cells indicate protective effects of SCN − , acute exposures to bolus doses of HOSCN causes cytotoxicity in J774A.1 murine macrophage-like cells, HUVECs and HCAECs [147-149]. These observations suggest HOSCN can injure mammalian cells in certain contexts by oxidizing sensitive thiol targets, though the studies are discordant regarding the mechanism of cell death.…”
Section: Effects Of Scn− On Mammalian Cells and Biological Systemsmentioning
confidence: 99%
“…These observations suggest HOSCN can injure mammalian cells in certain contexts by oxidizing sensitive thiol targets, though the studies are discordant regarding the mechanism of cell death. However, prolonged HOSCN exposure enhances HUVEC viability [148] and HCAEC fare better when exposed to HOSCN compared with HOCl [149]. J774A.1 cells were very sensitive to high dose HOSCN-mediated apoptosis and, strikingly, resistant to HOCl [147]; however, in another study these cells were sensitive to HOCl and protected by SCN − [15].…”
Section: Effects Of Scn− On Mammalian Cells and Biological Systemsmentioning
confidence: 99%