Comparison of Antibacterial Activity of Fluoroquinolones with Their Sucralfate-complexes against Clinically-isolated Bacteria

Abstract

Oral fluoroquinolones are widely known to form chelate complexes with metal-containing drugs, resulting in inhibition of their intestinal absorption. However, for intestinal sterilization, the concomitant regimen may be a selective and effective strategy due to decreased absorption of fluoroquinolones result in the retainment of antibiotics at the intestine if the mixture still perpetuated antibacterial activity. Therefore, to clarify whether the mixture of fluoroquinolones and sucralfate affects their antibacterial activity or not, we conducted in vitro study. According from the checkerboard study using a microdilution method with Mueller-Hinton broth, the antibacterial activity of these fluoroquinolones-sucralfate mixtures equaled to the parent fluoroquinolones even in the presence of sucralfate at the molar ratio of

Randomized controlled trial of topical mupirocin versus mupirocin with sucralfate combination in chronic skin ulcers

“…[56] Experimental evidence exists to suggest that sucralfate may promote wound healing for instance in burn wounds. [7] Sucralfate also has antibacterial activity[89] and has been successfully studied in decreasing pain and improving healing after hemorrhoidectomy, in ulceration and erosion of the perineal area, in ulceration of the vagina, in peristomal and perineal dermatoses, in moist desquamation during radiotherapy, in epidermolysis bullosa, and in burns of the second and third degrees. [1011121314151617] In a pilot study, it has shown benefit in full-thickness, venous stasis ulcers not healing after 8 weeks of conventional therapy.…”