Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice

Fatty Acids and Sterol Rich Stem Back Extract of Shorea Roxburghii Attenuates Hyperglycemia, Hyperlipidemia, and Oxidative Stress in Diabetic Rats

“…[23][24][25] Quite a number of reports have indicated that medicinal plants or their bioactive constituents have the ability to stimulate the production and activity of insulin as well as enhance the regeneration of pancreatic -cells in diabetic models. [26][27][28][29] Our findings indicated normalization of HOMA-IR and pancreatic histopathology in MESS treated animals, which were grossly impaired in diabetic animals. These results suggest that MESS may act as an insulin secretagogue as well as prevents -cell damage or stimulate the regeneration of pancreatic -cell.…”

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

“…Hyperglycemia often produces an elevated reactive oxygen species in β -cells, providing succeeding impairment to cellular mechanisms [69,70]. The pancreatic lipid contents generally not relate with β -cell dysfunction in young-onset T2DM [71] and, however, pancreatic islet lipotoxicity is known as a major factor for the onset and progression of T2DM. The disorder of lipid metabolism or increasing fatty acid levels in the blood cause β -cell dysfunction, which are primary threat factors for T2DM [39].…”

Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats

“…11 Fruit extracts can increase insulin secretion and protect the pancreas, inhibit α-glucosidase and inhibit α-amylase. [12][13][14] Innovations in oral antidiabetic agents from natural ingredients have been developed. The use of a single dose in the treatment of diabetes is often considered to lack a strong effect.…”