Comparison of Histological and Three-Dimensional Characteristics of Porous Titanium Granules and Deproteinized Bovine Particulate Grafts Used for Sinus Floor Augmentation in Humans

Vandeweghe, Stefan; Leconte, Carole; Ono, Daisuke; Coelho, Paulo G.; Jimbo, Ryo

doi:10.1097/id.0b013e3182938d03

Cited by 17 publications

(22 citation statements)

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“…19 However, it is not clear whether the material can be used successfully for two-stage sinus lift procedures because of the possible risk of displacement of the granules and insufficient stability of the implant during site preparation. Further studies should evaluate this application in animal models.…”

Section: Discussionmentioning

confidence: 99%

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Porous titanium granules in critical size defects of rabbit tibia with or without membranes

et al. 2014

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Recently, porous titanium granules (PTGs) have been indicated for the preservation of the dimensions of post-extraction sockets, as a filler in sinus lift procedures and for the treatment of peri-implant and periodontal defects, based on the osteoconductivity and dimensional stability of the titanium granules. However, there is a lack of information regarding the use of this material in larger defects and in conjunction with membranes. The objective of this study is to test the behavior of PTGs used to fill critical size defects in rabbit tibiae, with and without membranes. Critical defects were created in both tibiae of rabbits, divided randomly into three groups: Group A (defect filled with PTG), Group B (defect filled with PTG+collagen membrane) and a control group (empty defect). After six weeks, histomorphometric analysis was performed. The results showed more defect closures at the cortical area (87.37%±2.2%) and more bone formation at the marrow area (57.6%±1.3%) in Group B, in comparison with the other groups (P<0.05); the use of membranes improved the material stability expressed as more percentages of the original material when membranes were used (P<0.05). Finally, inflammatory reactions were observed when the granules were not protected by membranes. In spite of the limitations of this animal study, it may be concluded that PTG particles are osteoconductive and allow bone growth. The PTG particles must be covered by a membrane, especially when grafting larger defects, in order to control particle migration, promote clot stabilization and separate the PTG graft from undesired soft tissue cells.

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Section: Discussionmentioning

confidence: 99%

“…Recently, porous titanium granules (PTGs) have been indicated for the preservation of the dimensions of the post-extraction socket, 13,14,15 as a filler in sinus lift procedures 16,17,18,19 and for the treatment of peri-implant 20,21,22 and periodontal defects. 23,24 …”

Section: Introductionmentioning

confidence: 99%

Porous titanium granules in critical size defects of rabbit tibia with or without membranes

et al. 2014

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“…Atualmente técnica cirúrgica indicada é a de levantamento do assoalho do seio maxilar por ser confiável e previsível, possuir alta taxa de sucesso e baixa taxa de complicações cirúrgicas (Pjetursson et al, 2008;Vandeweghe et al, 2013) e promover um significativo aumento ósseo vertical da maxila atrófica possibilitando a colocação de implantes (Nkenke e Stelzle, 2009;Esposito et al, 2010;Lee et al, 2012). Segundo Wallace e Froum (2003), a cirurgia de levantamento de seio maxilar (LSM) possui três objetivos: 1º) a formação de tecido ósseo vital no seio pneumatizado, 2º) a integração dos implantes neste tecido e 3º) sobrevivência em longo prazo desses implantes quando colocados sob carga funcional.…”

Section: Revisão De Literaturaunclassified

“…Atualmente, o material ósseo-substituto mais utilizado Sbordone et al, 2011;Mordenfeld et al, 2015) e estudado clínica e histologicamente para LSM (Jensen, Schou, et al, 2012b;a;Manfro et al, 2014;Moon et al, 2015), é a matriz óssea inorgânica de origem bovina denominada Bio-Oss® (Geistlisch Farmacêutica, Wolhusen, Suíça); podendo ser considerado referência entre os materiais não autógenos (Vandeweghe et al, 2013;Calasans-Maia et al, 2015) e padrão-ouro como osso bovino inorgânico para a técnica cirúrgica de LSM (Manfro et al, 2014). Muitos estudos utilizando o Bio-Oss® na técnica cirúrgica de LSM em seres humanos têm apresentado resultados favoráveis mesmo no longo prazo (Yildirim et al, 2000;Traini et al, 2007;Mordenfeld et al, 2010;Lee et al, 2012;Ayna et al, 2015;Lutz et al, 2015;Schmitt et al, 2015).…”

Section: Revisão De Literaturaunclassified

“…Dentre os materiais ósseo-substitutos não autógeno, o mais estudado e bem documentado na literatura é o Bio-Oss®, um osso xenógeno inorgânico de origem bovina, que devido ao grande sucesso na sua utilização pode ser considerado referência entre os materiais ósseo-substitutos não autógeno (Vandeweghe et al, 2013;Calasans-Maia et al, 2015). O Bio-Oss® possui excelente propriedade osteocondutora permitindo a deposição óssea diretamente em sua superfície (Yildirim et al, 2000;Ayna et al, 2015).…”

Section: Introductionunclassified

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Avaliação microtomográfica e histomorfométrica comparativa de levantamento de seio maxilar em coelhos utilizando diferentes cerâmicas a base de fosfato de cálcio

Santos¹

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Vertical bone augmentation with titanium granule blocks in rabbit calvaria

Abrahamsson¹,

Wälivaara²,

Anderud³

et al. 2017

Clinical & Exp Dental Res

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To determine whether it is possible to vertically augment bone utilizing a block graft from compressed titanium granules mainly used previously for contained bone defects and to determine whether there exists a difference in osteoconductive properties between the white and the grey granules. In 11 rabbits, 4 titanium blocks were inserted on each rabbit's skull bone according to a randomized scheme. These blocks were made from standardized compressed titanium granules. Type A: PTG grey, small granules (Pourus Titanium Granules, Tigran, Malmö, Sweden); Type B: PTG grey, large granules; Type C: PTG white, small granules; Type D: PTG white large granules. After 12 weeks, the animals were sacrificed and specimens were collected for histology and μCT scanning. From both the μCT and histology, it can be said that bone formation was successfully achieved for all groups, and the granules maintained their volume. The histomorphometric BA (bone area) evaluation in the entire grafted area presented that there were no statistical differences between all groups tested. The lowest 1/4 BA in contact with the rabbit skull presented that groups A and C presented the highest mean BA, and group A presented significantly higher BA than that of group D (p = 0,049). No significant differences were noted between groups A, B and C. Within the limitation of this study, no differences were noted between small white or grey PTG blocks. The large granules presented less bone ingrowth area compared to the small granules and this trend was regardless of the different PTG types. The entire grafted area was not filled with new bone suggesting that bone migration occurred mostly from the existing cortical bone side suggesting contact osteogenesis.

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Comparison of Histological and Three-Dimensional Characteristics of Porous Titanium Granules and Deproteinized Bovine Particulate Grafts Used for Sinus Floor Augmentation in Humans

Abstract: From a bone formation perspective, PTG grafts were comparable with the commonly used Bio-Oss grafts and may be regarded as a possible alternative for permanent grafting in sinus augmentation.

Cited by 17 publications

References 32 publications

Porous titanium granules in critical size defects of rabbit tibia with or without membranes

Porous titanium granules in critical size defects of rabbit tibia with or without membranes

Avaliação microtomográfica e histomorfométrica comparativa de levantamento de seio maxilar em coelhos utilizando diferentes cerâmicas a base de fosfato de cálcio

Vertical bone augmentation with titanium granule blocks in rabbit calvaria

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