No abstract

Abstract:Nanostructure modification of dental implants has long been sought as a mean to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we described a nanoscale hydroxyapatite (HA) coated implant surface and hypothesized that it will hasten osseointegration and improve its quality relative to non-coated implants. Twenty threaded titanium alloy implants, half prepared with stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat treated (HT), were inserted into rabbit femurs. Preoperatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. Moreover, the nanomechanical properties of the surrounding bone were evaluated using nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

The results proved that the enhanced photo-induced hydrophilicity of the NH(4) F-HF(2) -modified anodized implants promoted bone apposition during the early stages of osseointegration.

From a bone formation perspective, PTG grafts were comparable with the commonly used Bio-Oss grafts and may be regarded as a possible alternative for permanent grafting in sinus augmentation.

The newly developed β-TCP blocks presented subsequent replacement by newly formed bone, in conjunction with maintaining the external morphology.