Comparison of human mesenchymal stem cells proliferation and differentiation on poly(methyl methacrylate) bone cements with and without mineralized collagen incorporation

Wu, Jingjing; Xu, Suju; Qiu, Zhiye; Liu, Peng; Liu, Huiying; Yu, Xiang; Cui, Fu Zhai; Chun-hua, Zhao

doi:10.1177/0885328215582112

Cited by 15 publications

(8 citation statements)

References 49 publications

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“…Moreover, Wu et al proved that osteogenic differentiation on MC incorporated in poly bone cement was more than two times higher than that of poly alone after culturing for 21 day in human marrow mesenchymal stem cells culture system. 36 The result con rmed the important mechanism on osteogenic properties of MC at cellular level.…”

Section: Discussionmentioning

confidence: 59%

Clinical efficacy of Mineralized Collagen (MC) versus Bio-Oss for immediate implant implantation in esthetic area: a single-center retrospective clinical study

Dai

Han

et al. 2021

Preprint

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Background: The purpose of this retrospective clinical study was to evaluate the clinical efficacy of mineralized collagen (MC) versus Bio-Oss for immediate implant implantation in esthetic area. Methods: Medical records of Department of Oral and Maxillofacial Surgery of Shandong Provincial Hospital were screened for patients who had been treated with immediate implant implantation in the esthetic area using either MC( Allgens®) or Bio-Oss®, between January 2018 and December 2019. All patients fulfilling the in-/exclusion criteria and following for a minimum period of 1 year after surgery were enrolled into the presented study. Implant survival rate, radiographic, esthetic and patient satisfactory evaluations were performed.Results: Altogether, 70 patients were included in the study; a total of 80 implants were inserted. All implants had good initial stability after implantation. The survival rate of implants was 100% at 1-year follow-up. The differences in horizontal and vertical bone loss between the Trail group (0.72±0.26mm, 1.62±0.84mm) and the Control group (0.70±0.52 mm, 1.57±0.88mm) were statistically no significant at 6 months after permanent restoration. Similar results occurred at 12 months after permanent restoration. Clinical acceptability defined by PES ≥ 6 (6.07±1.62 vs. 6.13±1.41) was not significantly different between groups. Patient satisfaction estimated by VAS was similar (8.56±1.12 vs. 8.27±1.44), and the difference was not statistically significant between the two groups.Conclusions: The biomimetic MC seems to be a suitable and feasible option for bone graft material in immediate implant implantation.

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Section: Discussionmentioning

confidence: 59%

Clinical efficacy of Mineralized Collagen (MC) versus Bio-Oss for immediate implant implantation in esthetic area: a single-center retrospective clinical study

Dai

Han

et al. 2021

Preprint

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“…The in vitro osteogenic capacity of the MC has been proved in our previous works [ 21 , 26 ]. To confirm the osteogenic property of c MC, reverse transcription polymerase chain reaction (RT-PCR) was used to test the expression of osteogenesis-related genes.…”

Section: Methodsmentioning

confidence: 98%

A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep

Wang

Zhao

Yang

et al. 2018

Regenerative Biomaterials

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Large-sized cranial bone defect repair presents a great challenge in the clinic. The ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support, excellent biocompatibility, good osseointegration and biodegradability as well. In this study, a high-strength mineralized collagen (MC) bone scaffold was developed with biomimetic composition, microstructure and mechanical properties for the repair of sheep large-sized cranial bone defects in comparison with two traditional cranioplasty materials, polymethyl methacrylate and titanium mesh. The compact MC scaffold showed no distinct pore structure and therefore possessed good mechanical properties. The strength and elastic modulus of the scaffold were much higher than those of natural cancellous bone and slightly lower than those of natural compact bone. In vitro cytocompatibility evaluation revealed that the human bone marrow mesenchymal stem cells (hBMSC) had good viability, attachment and proliferation on the compact MC scaffold indicating its excellent biocompatibility. An adult sheep cranial bone defect model was constructed to evaluate the performances of these cranioplasty materials in repairing the cranial bone defects. The results were investigated by gross observation, computed tomography scanning as well as histological assessments. The in vivo evaluations indicated that compact MC scaffold showed notable osteoconductivity and osseointegration with surrounding cranial bone tissues by promoting bone regeneration. Our results suggested that the compact MC scaffold has a promising potential for large-sized cranial bone defect repair.

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“…[ 10 – 14 ] As demonstrated in previous studies, compound modification by using MC can significantly reduce elastic modulus of PMMA bone cement without influencing the strength, as well as improving compatibility with adjacent bone tissue to form osseointegration. [ 9 , 15 , 16 ] Our department has been using MC modified PMMA to treat OVCF since June 2013 and has compared treatment outcomes with traditional PMMA. Clinical observations were followed-up and outcomes were analyzed.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome comparison of polymethylmethacrylate bone cement with and without mineralized collagen modification for osteoporotic vertebral compression fractures

et al. 2018

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A retrospective study of consecutive patients.The purpose of this study was to compare the clinical effect of biomimetic mineralized collagen (MC) modified polymethylmethacrylate (PMMA) bone cement and traditional PMMA bone cement for the treatment of osteoporotic vertebral compression fractures (OVCF).New fracture on adjacent level is the major postoperative complication of percutaneous vertebroplasty (PVP). The clinical incidence was 12.4% to 27.7%. The increased stiffness of the treated vertebral body caused by filling bone cement is considered as one of the main reasons.A total of 30 patients treated with traditional PMMA bone cement from June 2013 to March 2016 were selected as the traditional group, while 50 patients treated with MC modified PMMA bone cement from July 2014 to March 2016 were selected as the modified group. The 2 groups were compared by injection time of the bone cements, postoperative pain relief effects, vertebral height restoration, CT value changes of the treated vertebral bodies, and postoperative complications in the clinical observations.The surgeries were successfully completed in both groups. In the treatment of OVCF, the MC modified bone cement was able to achieve the same pain relief and vertebral height restoration effects compared to traditional bone cement during the follow-ups, although the injection time of the cement was prolonged in the operation. MC modified bone cement significantly reduced the incidence of postoperative adjacent vertebral fracture from 13.3% to 2%, and significantly increased bone density of the treated vertebral bodies.The MC modified PMMA bone cement showed good clinical outcomes and better mechanical properties than the traditional bone cements.

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Comparison of human mesenchymal stem cells proliferation and differentiation on poly(methyl methacrylate) bone cements with and without mineralized collagen incorporation

Cited by 15 publications

References 49 publications

Clinical efficacy of Mineralized Collagen (MC) versus Bio-Oss for immediate implant implantation in esthetic area: a single-center retrospective clinical study

Clinical efficacy of Mineralized Collagen (MC) versus Bio-Oss for immediate implant implantation in esthetic area: a single-center retrospective clinical study

A high-strength mineralized collagen bone scaffold for large-sized cranial bone defect repair in sheep

Clinical outcome comparison of polymethylmethacrylate bone cement with and without mineralized collagen modification for osteoporotic vertebral compression fractures

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