Therefore, the study of the coupling characteristics of the substrate as well as the crosstalk and noise reduction techniques, are becoming more and more important [3]. Many investigations have demonstrated and explained the great interest of SOI devices for substrate crosstalk reduction [4][5]. Nevertheless, the optimization of the substrate behavior from a crosstalk point of view is not the only way to do it. Circuit design rules can also reduce the risk of substrate crosstalk [6]. In this context, it is well known that it is better to design analog differential devices. For digital circuits, due to logical and physical considerations, designers put ground lines near signal ones and within the same metal layer to get a differential configuration rather than a common one. This case is illustrated in Fig.1b, where arrows depict the coupling between the two wires. From an electromagnetic point of view, it means that one should excite the differential (odd mode) mode rather than the common one (even mode): in the latter, the substrate acts as a ground plane, and thus the return longitudinal currents in the substrate as well as the shunt currents can both give rise to a significant substrate crosstalk.