Comparison of the Enhancement of Plasma Glucose Levels in Type 2 Diabetes Otsuka Long-Evans Tokushima Fatty Rats by Oral Administration of Sucrose or Maple Syrup

Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms

“…(237^9 mg/dl) [19], and Otsuko LongEvans Tokushima Fatty (222^6 mg/dl) rat models [20]. The study also showed that in agreement with earlier studies [13], placement of Plexiglass clips on renal arteries led to renal hypertension 4 weeks after the operation.…”

“…Six weeks after the induction of diabetes, renal hypertension (two-kidney, one clip) was induced as described previously [20]. Briefly, under ketamin (60 mg/ kg) and xylazine anesthesia (8 mg/kg), left kidney was exposed via an incision in the left flank, and left renal artery and veins were exposed, separated, and cleaned of surrounding tissues.…”

Changes in Plasma Glucose in Otsuka Long-Evans Tokushima Fatty Rats After Oral Administration of Maple Syrup

“…In addition, the phenolic compounds in maple syrup may possess antioxidant activity 8 , and an in vitro study of a butanol extract of maple s y r u p d e m o n s t r a t e d i n h i b i t o r y a c t i v i t y t o w a r d α-glucosidase 14 . We also reported that the increase in plasma glucose PG is lower after the oral administration of maple syrup that has been prepared by dissolving maple sugar in water than after the administration of sucrose in the Otsuka Long-Evans Tokushima Fatty OLETF rat, a model of type 2 diabetes mellitus 15,16 . These data suggest the possibility that maple syrup might be used to prevent obesity and the development of diabetes mellitus compared Abstract: We investigate whether maple syrup is a suitable sweetener in the management of type 2 diabetes using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat.…”

Administration of a maple syrup extract to mitigate their hepatic inflammation induced by a high-fat diet: a transcriptome analysis

“…This may be the first report that have shown a health benefit of maple syrup found to confer a liver-protecting effect in animals. 1) Nagai et al 2) have reported that oral administration of maple sugar results in lowering plasma glucose levels in 30-and 60-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Apostolidis et al 3) showed that a butanol extract of maple syrup inhibits α-glucosidase in vitro, possibly by preventing elevation of plasma glucose levels in maple syrup-fed OLETF rats.…”