Comparison of total urinary estrogens and serum cystine aminopeptidase estimations in pregnancy

Tovey, J. E.; Sykes, John; Robinson, Derek; Hurry, David J.; Cooper, K; Beynon, Constance L.

doi:10.1016/s0009-9120(72)80016-x

Cited by 6 publications

(4 citation statements)

References 3 publications

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“…These observations indicate that CAP Acta Obstet Gynec Scand 53 (1974) and oestriol are measuring different parameters, that one test cannot substitute for the other, but that they are complementary. The same conclusion has been made by Petrucco et al (6) and Tovey et al (7). Tovey concluded that CAP estimations were superior to oestriol assays for the prediction of intra-uterine foetal growth retardation.…”

Section: Discussionsupporting

confidence: 76%

Cystine Aminopeptidase Activity in Pregnancy

Rydén¹

1974

Acta Obstet Gynecol Scand

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Abstracr. Maternal cystine aminopeptidase activity (CAP) and total urinary oestriol excretion have been compared in I I normal patients between 30 and 41 weeks gestation, in 9 patients with toxaemia of pregnancy and in 3 patients with a history of complication during the actual or previous pregnancy. The statistical correlation between maternal CAP and oestriol excretion in normal patients was poor (r=0.32). In patients with preeclampsia the results were as follows: low CAP levels generally were associated with low oestriol excretion, whereas with high or normal CAP values there were varying levels of oestriol. CAP levels in blood are only related to the function of the placenta, whereas the oestriol excretion is related to the condition of the whole fetoplacental unit. Therefore serial CAP assays cannot replace oestriol assays in assessing the condition of the foetus and placenta. However, in some patients where intrauterine fetal death occurred, decreasing CAP values were observed before there was a significant change in oestriol excretion. This indicates that decreased placental function might be observed at an earlier stage using CAP than using oestriol determinations. CAP assay is therefore justified as a valuable test alongside estimation of oestriol excretion in judging the condition of the placenta during the last trimester. As the methods of CAP assays are simple and reproducible, CAP can be used on a large scale for detecting and monitoring pregnancies at risk, in order to get a more diversified picture with respect to the condition of the fetus and placenta during the last trimester.

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Section: Discussionsupporting

confidence: 76%

Cystine Aminopeptidase Activity in Pregnancy

Rydén¹

1974

Acta Obstet Gynecol Scand

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“…This was in contrast to the conclusions of Chapman et al (1971), who felt that oestrogen excretion provided no more information with regard to fetal outcome than did the estimation of serum cystine aminopeptidase, and to those of Tovey et al (1972) who also suggested that assays of this enzyme were of comparable overall value to those of urinary oestrogen. These investigators found that both assays were helpful in 60 % and misleading in 27 % of complicated pregnancies.…”

contrasting

confidence: 76%

“…Urinary pregnanediol and maternal serum heat stable alkaline phosphatase are now regarded as inefficient indices of feto-placental function and are generally considered to contribute little to the management of the patient. The value of oxytocinase assays is still in debate, but the results presented so far appear, at best, to give no more information than do oestrogen assays (Tovey et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…Tovey (1969) reported plasma CAP activities which failed to show a normal rise in four patients with varying degrees of hypertension who were all delivered of babies with some degree of dysrnaturity, and Josephides and Turkington (1967) studied two patients with severe pre-eclampsia where there was a decrease in CAP activity before fetal death occurred, although in one of these cases there was a rise immediately prior to death which continued for a time after the termination. In a study of 50 pregnancies with various complications, Tovey et al (1972) found serial assays helpful in 64 %and misleading in 28 %of these cases.…”

Section: Cystine Aminopeptidase (Oxytocinase)mentioning

confidence: 98%

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