Comparison of virtual and titanium clip marking of tumour resection margins for improved radiation planning in head and neck cancer surgery

Bittermann, Gido; Ermer, Michael Andreas; Voss, Pit Jacob; Duttenhoefer, Fabian; Zimmerer, Rüdiger; Schmelzeisen, Rainer; Metzger, Marc Christian

doi:10.1016/j.ijom.2015.07.013

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…It is well established that it is critical to treat tumor margins for disease control in HN cancer, 34 , 35 where its surface is a part of these margins. The simulated light dose distributions for deformed tumor varies by up to 5.4% from its predeformed shape ( Table 5 ).…”

Section: Resultsmentioning

confidence: 99%

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Reconstruction of a Deformed Tumor Based on Fiducial Marker Registration: A Computational Feasibility Study

Han

Oakley

Shafirstein

et al. 2018

Technol Cancer Res Treat

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Interstitial photodynamic therapy has shown promising results in the treatment of locally advanced head and neck cancer. In this therapy, systemic administration of a light-sensitive drug is followed by insertion of multiple laser fibers to illuminate the tumor and its margins. Image-based pretreatment planning is employed in order to deliver a sufficient light dose to the complex locally advanced head-and-neck cancer anatomy, in order to meet clinical requirements. Unfortunately, the tumor may deform between pretreatment imaging for the purpose of planning and intraoperative imaging when the plan is executed. Tumor deformation may result from the mechanical forces applied by the light fibers and variation of the patient’s posture. Pretreatment planning is frequently done with the assistance of computed tomography or magnetic resonance imaging in an outpatient suite, while treatment monitoring and control typically uses ultrasound imaging due to considerations of costs and availability in the operation room. This article presents a computational method designed to bridge the gap between the 2 imaging events by taking a tumor geometry, reconstructed during preplanning, and by following the displacement of fiducial markers, which are initially placed during the preplanning procedure. The deformed tumor shape is predicted by solving an inverse problem, seeking for the forces that would have resulted in the corresponding fiducial marker displacements. The computational method is studied on spheres of variable sizes and demonstrated on computed tomography reconstructed locally advanced head and neck cancer model. Results of this study demonstrate an average error of less than 1 mm in predicting the deformed tumor shape, where 1 mm is typically the order of uncertainty in distance measurements using magnetic resonance imaging or computed tomography imaging and high-quality ultrasound imaging. This study further demonstrates that the deformed shape can be calculated in a few seconds, making the proposed method clinically relevant.

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Section: Resultsmentioning

confidence: 99%

“…It is well established that it is critical to treat tumor margins for disease control in HN cancer. 34 , 35 The tumor surface is part of the margin. Thus, it would be important to assure that the prescribed light dose is delivered to the surface of the deformed tumor.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of a Deformed Tumor Based on Fiducial Marker Registration: A Computational Feasibility Study

Han

Oakley

Shafirstein

et al. 2018

Technol Cancer Res Treat

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“…Vernier Callipers 2. Ruler 3.Caliper gauge were used in the facilities [4]. When the distance from the lesion to the oral floor or the ipsilateral posterior tongue base is measured, these scales might be hindered by the lips, teeth and the buccal mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…In the patients with tongue cancer, adequate and accurate designed surgical margin are very important regarding local recurrence, clinical metastasis, and survival rate [1][2][3][4]. We describe a simple and cheap self-designed scale that is a very effective instrument from our experience for partial glossectomy and tumor excision in oral cavity.…”

Section: Introductionmentioning

confidence: 99%

A Simple Self-Made Scale to Design Surgical Margin in Tongue Cancer: Technical Note

et al. 2017

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We report a simple and cheap self-designed scale that is a very effective instrument for partial glossectomy and tumor excision in oral cavity. This scale could be placed on the surface of the mucosa to design the adequate and accurate surgical margin with forceps. In addition, this scale can be attached on the surface of the mucosa without holding by the forceps. Its effectiveness and safety were identified for glossectomy, tumor excision in our experience. Keywords: Surgical margin, Self-made scale, Ruler, Tongue cancer, Leukoplakia, Benign tumor

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“…However, for adequate treatment of craniofacial tumors, computer-aided visualization and planning of 3D image data are necessary for all disciplines involved. For this purpose, an interdisciplinary image viewing interface would be required to visualize multimodal image data (computer tomography (CT), magnetic resonance imaging (MRI), cone beam-CT (CBCT), positron emission tomography (PET), PET/CT, and single photon emission computed tomography (SPECT)) for diagnostics, therapy planning, therapy sequence, treatment response, and search for distant metastasis or quality control [ 9 , 10 ]. Mixed reality (MR) technology, as a new tool in medicine and other disciplines, is a possible digital step in this direction.…”

Section: Introductionmentioning

confidence: 99%

Advances and Innovations in Ablative Head and Neck Oncologic Surgery Using Mixed Reality Technologies in Personalized Medicine

Karnatz

Möllmann

Wilkat

et al. 2022

JCM

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The benefit of computer-assisted planning in head and neck ablative and reconstructive surgery has been extensively documented over the last decade. This approach has been proven to offer a more secure surgical procedure. In the treatment of cancer of the head and neck, computer-assisted surgery can be used to visualize and estimate the location and extent of the tumor mass. Nowadays, some software tools even allow the visualization of the structures of interest in a mixed reality environment. However, the precise integration of mixed reality systems into a daily clinical routine is still a challenge. To date, this technology is not yet fully integrated into clinical settings such as the tumor board, surgical planning for head and neck tumors, or medical and surgical education. As a consequence, the handling of these systems is still of an experimental nature, and decision-making based on the presented data is not yet widely used. The aim of this paper is to present a novel, user-friendly 3D planning and mixed reality software and its potential application for ablative and reconstructive head and neck surgery.

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Comparison of virtual and titanium clip marking of tumour resection margins for improved radiation planning in head and neck cancer surgery

Cited by 11 publications

References 24 publications

Reconstruction of a Deformed Tumor Based on Fiducial Marker Registration: A Computational Feasibility Study

Reconstruction of a Deformed Tumor Based on Fiducial Marker Registration: A Computational Feasibility Study

A Simple Self-Made Scale to Design Surgical Margin in Tongue Cancer: Technical Note

Advances and Innovations in Ablative Head and Neck Oncologic Surgery Using Mixed Reality Technologies in Personalized Medicine

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