Complement and coagulation: strangers or partners in crime?

Evidence for non-traditional activation of complement factor C3 during murine liver regeneration

“…This conclusion is particularly intriguing in light of a recently published report demonstrating non-traditional (C3-independent) activation of C5 by thrombin both in vivo in a murine model of lung injury and in vitro (Huber-Lang et al 2006), and raise the possibility that thrombin or other factors may also promote C3 activation during liver regeneration. Based on such analyses and recently reported observations highlighting the existence of crosstalk between the complement and coagulation proteolytic cascades (Markiewski et al 2007), the effects of thrombin and plasmin on in vitro C3 activation were determined. The results showed that both of these proteases can promote the generation of activated C3α, and furthermore that under the experimental conditions employed here plasmin can promote such activation in the absence of factor B ( Figure 5).…”

Platelet Mediated Complement Activation

“…Increasing evidence is emerging to support cross-talk between coagulation and complement systems Markiewski, Nilsson, Ekdahl, Mollnes, and Lambris 2007). In this regard, PMP present a surface for the assembly and interaction of complement and coagulation cascades.…”

Transcriptome analysis of soiny mullet (Liza haematocheila) spleen in response to Streptococcus dysgalactiae

“…Within the molecular function category, the five most abundant subcategories were binding (14,870,66.05%), catalytic activity (9,274, 38.17%), enzyme regulator activity (1,450, 5.97%), transporter activity (1,332, 5.48%), and molecular transducer activity (1,313, 5.4%). In the cellular component category, cell (17,212,70.83%), cell part (17,211, 70.83%), organelle (12,859, 52.92), membrane (8,461,34.82%) and organelle part (7,957,32.75%) were the most common subcategories. While in the biological process category, most unigenes were assigned into cellular process (18,323,75.4%), single-organism process (15,185,62.49%), metabolic process (14,025, 57.72%), biological regulation (11,709, 48.19%) and regulation of biological process (11,047, 45.46%) subcategories (Fig.…”

“…The complement system and coagulation system are important parts of innate immune system which interact together and act as "first line of defense" during microbial invasion [32,33]. Current researches mainly focus on the mammalian complement and coagulation system but few on that of fish.…”