Complete Genome Sequences of Four European Subtype Strains of Tick-Borne Encephalitis Virus from Eastern Siberia, Russia

Adelshin, R. V.; Мельникова, О. В.; Karan, Ludmila S.; Андаев, Е. И.; Балахонов, С. В.

doi:10.1128/genomea.00609-15

Cited by 17 publications

(5 citation statements)

References 6 publications

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“…Considering TBEV-E as a separate species is also of practical importance. In particular, two commercially available vaccines for TBEV prevention based on the K23 and Neudoerfl strains (TBEV-E), namely Encepur ("Novartis Vaccines and Diagnostics" Germany) and FSME Immun Inject ("Baxter", Austria) have been used in Russia (Siberia region) until 2015 despite that TBEV-E isn't widespread in this territory (in the literature, there are only isolated cases are described (Adelshin et al, 2015;Demina et al, 2010;Demina et al, 2017)). Our results showed significant differences in phylogenetic pairwise distances of antigenic determinants of main TBEV subtypes and LIV.…”

Section: Discussionmentioning

confidence: 99%

Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa

Bondaryuk

Андаев

Dzhioev

et al. 2022

Molecular Phylogenetics and Evolution

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Section: Discussionmentioning

confidence: 99%

Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa

Bondaryuk

Андаев

Dzhioev

et al. 2022

Molecular Phylogenetics and Evolution

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“…В Восточной Сибири штаммы ВКЭ европейского субтипа были выделены от суслика длиннохвостого (Spermophilus undulatus), узкоче-репной полевки (Microtus gregalis), лесной мыши (Apodemus sylvaticus), красной полевки (Myodes rutilus) [7], бурозубки (sp. Sorex) [13]. На территории Западной Сибири этот субтип вируса был изолиро-ван от грызунов: красно-серой полевки (Myodes rufocanus), красной полевки (M. rutilus), плоскоче-репной полевки (Alticola strelzovi), большеухой по-левки (A. macrotis), узкочерепной полевки (Microtus gregalis), полевки экономки (M. oeconomus), а так-же от зайцеобразных: алтайской пищухи (Ochotona alpina) [23].…”

Section: штаммы из западной сибириunclassified

The characterization of TBEV of European subtype circulating in Siberia, Russia

Козлова¹,

Демина²,

Tkachev³

et al. 2016

Epidemiology and Vaccine Prevention

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The aim of the study was to obtain the complex characteristics of tick-borne encephalitis virus (TBEV) of European subtype circulating in Western and Eastern Siberia. Using full-genome sequencing approach it was demonstrated that TBEV strains of European subtype isolated in Siberia are genetically similar to the strains from European part of its habitat range, and with the representatives from South Korea. It was confirmed that the homology of TBEV strains of European subtype isolated in different parts of the virus habitat area from Scandinavian countries in the west to the eastern borders of the area (South Korea) is much higher than the homology level of TBEV strains of Far Eastern and Siberian subtypes. The Siberian population of TBEV of European subtype is presented with two groups of strains called as Eastern Siberian and Western Siberian variants, which differ in the combinations of amino acid substitutions in all proteins except NS2B protein. It is found that TBEV strains of European subtype from Siberia possess high neurovirulence, but some of them, like strains from Europe, demonstrate low invasiveness. It is shown that TBEV strains of European subtype have good adaptive capacity, and therefore, can easily adapt to the circulation in various biocenoses in the territory of different landscape-geographical zones. It was found that the circulation of TBEV of European subtype is fixed in Siberia territory for over 40 years. It was emphasized that in spite of circulation of TBEV of European subtype in the significantly different areas by climatic conditions, topography, landscape, habitat characteristics it possesses a high degree of genome stability.

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“…ВКЭ-Сиб (или генотип 3) наиболее широко распространён по всему ареалу ВКЭ, доминирует на территории РФ, был изолирован в Казахстане (штамм Алма-Арасан [4]), но информация о его наличии в большинстве европейских стран, а также в Корее и Японии отсутствует. В Иркутской области и Республике Бурятия все три основных субтипа (генотипа) ВКЭ вовлечены в этиологию КЭ [5,6], и недавно появились первые данные о полногеномных структурах штаммов ВКЭ из Сибири [9][10][11] Нуклеотидные последовательности геномов штаммов ВКЭ для сравнительного анализа были определены нами в ходе настоящей работы или взяты из международной компьютерной базы данных GenBank.…”

Section: Introductionunclassified

Definition and Comparative Analysis of the Genomic Structure of Siberian Strains of Tick-Borne Encephalitis Virus of the European Subtype

Демина

Козлова

Tkachev

et al. 2018

Problems of Virology

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Tick-borne encephalitis virus (TBEV) is classified into three subtypes: Far Eastern (TBEV-FE), European (TBEV-EU) and Siberian (TBEV-SIB). In Russia, these are also called genotypes 1, 2 and 3, respectively. Geographically, TBEV-EU dominates in Central and Northern Europe, but its representatives are also found to the east - along the southern part of the forest zone of extratropical Eurasia - up to Eastern Siberia and South Korea. However, the strains isolated outside Europe remain poorly investigated. In the proposed study, eight full genomes of the Siberian isolates of TBEV-EU were determined and 13 complete genomes were compared. The analysis of 152 full-genome TBEV sequences showed that the TBEV-EU has a higher degree of stability of the genome-coding region in the entire Eurasian area (3.1% of differences) compared to TBEV-FE (6.6%) and TBEV-SIB (7.8%). At the same time, the maximum differences are observed not between European and Siberian strains, as one could expect, but between the representatives from Europe - TBEV strains Mandl-2009 from Norway and Hypr from the Czech Republic. The studied strains from Siberia form the compact genetic cluster of 42 TBEV-EU strains and are divided into two subclusters - West Siberian and East Siberian variants. These variants differ in the combinations of amino acid substitutions in all proteins except NS2B. The West Siberian variant mostly circulates in the territory of Altai, and the closest relative of its representatives is Absettarov strain from the European part of Russia. The strains similar to the East Siberian variant of the European subtype were recorded in the Altai (strain 84.2, 2007) and in Belarus (N256, about 1940).

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Complete Genome Sequences of Four European Subtype Strains of Tick-Borne Encephalitis Virus from Eastern Siberia, Russia

Abstract: Three tick-borne encephalitis virus (TBEV) strains were isolated from Ixodes persulcatus ticks, and one was isolated from a shrew in the territory of eastern Siberia (Russia). The level of sequence identity compared to Neudoerfl (the European prototype strain) is 97.2 to 97.3%.

Cited by 17 publications

References 6 publications

Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa

Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa

The characterization of TBEV of European subtype circulating in Siberia, Russia

Definition and Comparative Analysis of the Genomic Structure of Siberian Strains of Tick-Borne Encephalitis Virus of the European Subtype

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