Complex of Platinum(II) with Tris(2-carboxyethyl)phosphine Induces Apoptosis in Canine Lymphoma/Leukemia Cell Lines

Abstract

The cis-[PtCl(TCEP)] seems to be a potent anticancer agent, although further investigations are necessary to elucidate its biological activity.

Antitumor Activity of Betulinic Acid and Betulin in Canine Cancer Cell Lines

“…The anti-tumor effects of BA and BT were to some extent related to inhibited cell proliferation. Additionally, CLBL-1 line was the most sensitive to BA (the lowest IC 50 for BA in all three cell lines), which was concurrent with previous studies (26)(27)(28). It was suggested that B-cell lymphoma may be more sensitive to BA-based treatments.…”

In vitro effects of the activity of novel platinum (II) complex in canine and human cell lines

“…Nevertheless, the Pt‐TCEP was shown to have a considerably higher inhibitory effect than cisplatin on cell viability in canine and human OSA cell lines. This is in accordance with a previous study on canine leukaemia and lymphoma cell lines, in which the new compound was several times more effective than cisplatin in inducing cell apoptosis and death . Additionally, comparing the results of MTT assay with analysis of apoptosis level in the same concentrations and time of incubation, it can be concluded that at the lower concentrations the compound has mainly cytostatic effect, and with its increase, the reduction of cell viability is related to apoptosis as it is in the case of other platinum‐based drugs .…”

“…The study revealed that this agent was far more active in these cell lines in comparison to cisplatin. It was also confirmed that apoptosis was responsible for the observed cell death …”

Interaction of Newly Platinum(II) with Tris(2-carboxyethyl)phosphine Complex with DNA and Model Lipid Membrane

“…Recently, a new platinum-based compound containing a phosphine ligand tris(2-carboxyethyl)phosphine [P(CH 2 CH 2 COOH) 3 ] (TCEP) instead of ammonium group and two chlorine atoms in cis and trans conformation with potential anticancer activity has been introduced. The phosphane complexes exhibit cytotoxic activity against cisplatin resistant tumor cells and sometimes are more active than cisplatin (Pruchnik et al 2015 ; Henklewska et al 2017 ). Newly obtained platinum(II) complex with tris(2-carboxyethyl)phosphine (TCEP): cis -[PtCl 2 (TCEP) 2 ], which is the subject of this research exhibits interesting reactivity in solutions (Pruchnik et al 2015 ).…”