Complexation of fluoxetine hydrochloride with β-cyclodextrin. A proton magnetic resonance study in aqueous solution

19F-nuclear magnetic resonance spectroscopy as a tool to investigate host-guest complexation of some antidepressant drugs with natural and modified cyclodextrins

“…19F-NMR spectroscopy of mixtures of fluoxetine hydrochloride and different CDs revealed the existence of inclusion complexes formed by the penetration of CF3-substituted ring into the CD cavity, in analogy to previously reported findings for complex of fluoxetine with β-CD [3,7].…”

“…Due to formation of α-1,4-glycosidic linkage, CDs are doughnut shaped molecules, possessing hollow cavities which can accommodate a variety of guests in aqueous solution and in the crystalline state by non-covalent interactions [6,7]. The presence of hydroxyl groups on the exterior surface of CDs make them fairly polar while the interior of the cavity is relatively nonpolar.…”

“…The presence of hydroxyl groups on the exterior surface of CDs make them fairly polar while the interior of the cavity is relatively nonpolar. The slightly hydrophobic character of the inner cavity provides a driving force for hostguest complexation with similarly apolar guest molecules [7].…”

Application of Fluorescence Spectrometry With Multivariate Calibration to the Enantiomeric Recognition of Fluoxetine in Pharmaceutical Preparations

“…14,15 Only a few studies have described the pharmaceutical analysis of FLX enantiomers using other than chromatographic methods, namely, capillary electrophoresis 16 and NMR. 17,18 The enantiomeric composition identification of biologically active chiral compounds poses special challenges to scientists in the areas of environmental and pharmaceutical research. The new strategies of enantiomer resolution include chiral analysis by nonchirooptical methods, such as molecular spectroscopy with chemometric evaluation of data.…”

Determination of enantiomeric composition of fluoxetine by synchronous fluorescence spectrometry coupled with multivariate calibration in biological samples

“…Chromatographic methods, as LC or GC with chiral columns or chiral additives into mobile phase are typical for the determination of the FLX enantiomers (Lerena et al, 2003;Li et al, 2004;Mifsud and Sqhendo, 2012;Yu et al, 2012;Ribeiro et al, 2013). Few studies of FLX chiral analysis using non-chromatography methods such as capillary electrophoresis were published (Asensi-Bernardi et al, 2013) and NMR (Ali et al, 2005;Shamsipur et al, 2007). Our research presents the feasibility of FLX chiral analysis by combination of synchronous fluorescence spectrometry and inverse MVC methods (PCR and PLS) which were compared to obtain the best resolution of the FLX enantiomers in complicate biological matrix such as urine.…”