Composition and anti‐inflammatory activities of <i>Zanthoxylum schinifolium</i> essential oil: suppression of inducible nitric oxide synthase, cyclooxygenase‐2, cytokines and cellular adhesion

Lee, Je-Hyuk; Chang, Kyung‐Mi; Kim, Gun-Hee

doi:10.1002/jsfa.3653

Cited by 29 publications

(26 citation statements)

References 24 publications

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“…PF exerts its prokinetic activity via influencing the 5-HT 3 and 5-HT 4 receptor mediated pathways (47,48). In addition, ZF, has been reported to ameliorate delayed GIT as an agonist of cholinergic nerves and the 5-HT 4 receptor (22,23), which was confirmed in the present study using LD02GIFRO.…”

Section: Discussionsupporting

confidence: 84%

“…PF has been used as a traditional medicine for the treatment of abnormal gastrointestinal motility and gastric (18)(19)(20). ZF, which belongs to the Rutaceae family, has been used as a traditional medicine to alleviate stomach pain, diarrhea, and jaundice (21,22). Additionally, ZF extracts have been demonstrated to have a prokinetic effect that is able to ameliorate delayed gastrointestinal transit (GIT) in rats, and have been reported to stimulate duodenal and ileal motility (23,24).…”

Section: Introductionmentioning

confidence: 99%

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Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats

Choi

Zheng

Park³

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. LD02GIFRO is a novel prokinetic agent formulated with Poncirus fructus and Zanthoxylum sp. fruits. The aim of the present study was to evaluate the effect of LD02GIFRO on delayed gastrointestinal transit (GIT) and colorectal hypersensitivity. To investigate the effect of LD02GIFRO, a rat model of delayed GIT was induced via three mechanisms; postoperative ileus (POI), morphine, and POI plus morphine. Visceromotor responses (VMR) to colorectal distension (CRD) were also evaluated. POI was induced by laparotomy surgery and manipulation of the small intestine under anesthesia, and GIT was calculated by measuring the length that Evans Blue travelled through the gastrointestinal tract in a given time. Oral administration of 260 mg/kg LD02GIFRO caused Evans Blue to migrate significantly further in the delayed GIT models induced by POI, morphine and POI plus morphine compared with the control (P<0.05). This effect was inhibited by atropine, a muscarinic receptor antagonist, and completely abolished by GR125487, a 5-HT 4 -receptor antagonist. Furthermore, intraperitoneal administration of 600 and 900 mg/kg LD02GIFRO significantly reduced VMR to CRD in acute and chronic colorectal hypersensitive rat models, induced by acetic acid and trinitrobenzenesulfonic acid, to almost normal levels (P<0.01). In the present study, LD02GIFRO successfully ameliorated delayed GIT models and colorectal hypersensitivity models, suggesting that LD02GIFRO may be an effective therapeutic treatment for patients with functional gastrointestinal disorders and abnormalities in GIT.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats

Choi

Zheng

Park³

et al. 2017

Experimental and Therapeutic Medicine

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“…The reducing power of S. glabrescens extract-fractions was determined by Fe 3 ' reduction (Lee et al, 2009). S. glabrescens extract-fractions were mixed with 2.5 ml of 0.2 M phosphate buffer (pH 6.6) and 2.5 ml of 1% K 3 Fe(CN) 6 .…”

Section: Reducing Powermentioning

confidence: 99%

“…Cell viability was examined using an MTT assay (Lee et al, 2009). Macrophage cells were plated at a density of 1 )10 5 cells/well in 96-well tissue culture plate (Corning Inc., USA), and incubated at 378C for 3Á4 h. Plated cells were treated with indicated concentrations of S. glabrescens extract-fractions.…”

Section: Determination Of Cell Viabilitymentioning

confidence: 99%

“…The scavenging effect of S. glabrescens extract-fractions on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals were monitored according to the following procedure (Lee, Chang, & Kim, 2009). A 0.2 ml of methanolic solution containing extract-fractions was mixed with 4 ml of methanol, and a methanolic solution of DPPH (1 mmol/l, 0.5 ml) was added.…”

Section: Free Radical Scavenging Activitymentioning

confidence: 99%

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Evaluation for anti-inflammatory effects ofSiegesbeckia glabrescensextractin vitro

Lee

Kang

Hwang

et al. 2011

Food and Agricultural Immunology

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The aim of this study is to elucidate the anti-inflammatory effects of Siegesbeckia glabrescens extract in vitro. The n-butanol fraction (100 mg/ml) of S. glabrescens had an approximately 92% inhibitory effect on nitrite production from lipopolysaccharide (LPS)-induced macrophage cells, whereas other fractions showed relatively low nitric oxide (NO) inhibition. The n-butanol and ethyl acetate fractions of S. glabrescens showed significant chemical NO quenching to approximately 39Á46% in the cell-free system, and showed the decreases of inducible nitric oxide synthase (iNOS) transcription potently. The hexane, n-butanol, and ethyl acetate fractions of S. glabrescens showed approximately 90Á96% inhibition of prostaglandin E 2 (PGE 2 ) synthesis. The ethyl acetate, n-butanol, and aqueous fractions of S. glabrescens showed a potent inhibition of LPS-induced cyclooxygenase-2 (COX-2) mRNA transcription. All S. glabrescens extract-fractions showed significant decreases of IL-1b biosynthesis to 69.7Á 97.0%, as compared to LPS-induced IL-1b production in macrophage cells.

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