Composition and Antidiarrheal Activity ofBidens odorataCav.

Abstract

The antidiarrheal effects of chloroform, methanol, and aqueous extracts of Bidens odorata Cav. were investigated at doses of 200 mg/kg on castor-oil-induced diarrhea. The chloroform extract of B. odorata (CBO) reduced diarrhea by 72.72%. The effect of CBO was evaluated on mice with diarrhea induced by castor oil, MgSO4, arachidonic acid, or prostaglandin E2. CBO inhibited the contraction induced by carbachol chloride on ileum (100 µg/mL) and intestinal transit (200 mg/kg) in Wistar rats. The active fraction of CBO (F4) at doses of 100 mg/kg inhibited the diarrhea induced by castor oil (90.1%) or arachidonic acid (72.9%) but did not inhibit the diarrhea induced by PGE2. The active fraction of F4 (FR5) only was tested on diarrhea induced with castor oil and inhibited this diarrhea by 92.1%. The compositions of F4 and FR5 were determined by GC-MS, and oleic, palmitic, linoleic, and stearic acids were found. F4 and a mixture of the four fatty acids inhibited diarrhea at doses of 100 mg/kg (90.1% and 70.6%, resp.). The results of this study show that B. odorata has antidiarrheal effects, as is claimed by folk medicine, and could possibly be used for the production of a phytomedicine.

OBTENTION OF TRANSFORMED ROOTS CULTURES OF THE MEDICINAL PLANT Bidens odorata Cav (COMPOSITAE) AND PRELIMINARY PHYTOCHEMICAL ANALYSIS

“…Ya ha sido reportada la presencia del flavonoide quercetina y su contribución a las propiedades medicinales de la especie Bidens biternata (Zahara et al, 2015). Los flavonoides han sido asociados, entre otras cosas, con actividades antibacterial y antidiarreica (junto con los taninos), y B. odorata se emplea en México para el tratamiento de desórdenes gastrointestinales, tales como la diarrea (Zavala-Mendoza et al, 2013). En cuanto a los alcaloides, los reactivos de iodoplatinato ( fig.…”

“…Esta planta también se emplea para afecciones como dolor de huesos, de cabeza y de riñón y lumbar. Para heridas, diabetes, enfermedades de vías urinarias, anemia, irritación de la piel y para el tratamiento de la caída del cabello (UNAM, 2009), y así como para el tratamiento de la diarrea, cuyos efectos quedaron comprobados usando extractos acuosos (Zavala-Mendoza, Alarcon-Aguilar, Pérez-Gutierrez, Carmen Escobar-Villanueva, & Zavala-Sánchez, 2013). Hasta el momento no se ha hecho una caracterización fitoquímica completa de la especie B. odorata, sin embargo, en la especie B. pilosa se han aislado 198 productos naturales diferentes (F. L. Silva et al, 2011).…”

Freeze Dried extracts ofBidens biternata(Lour.) Merr. And Sheriff. show significant Antidiarrheal activity in ‐vivo Models of Diarrhea

“…The total mass of fecal output excreted after 4 hours was measured by subtracting the mass of the pre-weighed paper from the total mass of paper and fecal droppings. The results were expressed as a percentage of control according to the model described by Zavala-Mendoza ((Zavala-Mendoza et al, 2013) Charcoal meal test…”

Analgesic, Antidiarrheal and Antidepressant Activities of Anethum sowa Linn. in Swiss-Albino Mice Model

“…In some diarrhoeas, the secretory component predominants, while other diarrhoeas are characterized by hypermotility (Zubair et al, 2015). There are some drugs currently used for treating Correspondence to: Muhammad Abdullah Al-Mansur; E-mail: nayeembcsir@gmail.com; Tel: +88-01715010829 diarrhea but new agents are still required for improved treatment (Li et al, 2013;Zavala-Mendoza et al, 2013). In order to provide patient's safety and comfort regarding pain and diarrhea, plants might serve important sources of medicinal agents.…”