Comprehensive comparison of liquid chromatography selectivity as provided by two types of liquid chromatography detectors (high resolution mass spectrometry and tandem mass spectrometry): “Where is the crossover point?”

Kaufmann, Anton; Butcher, Patrick; Maden, Kathryn; Walker, Stephen; Widmer, Mirjam

doi:10.1016/j.aca.2010.05.020

Cited by 180 publications

(106 citation statements)

References 15 publications

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“…Many reports in the literature described the use of a narrow mass window to improve selectivity [20,21]. Figure 1 shows the chromatogram of a bovine liver extract spiked with marbofloxacin [21]. The detection relied on monitoring the [M+H] + ion by HRMS (Δm 10,000 full width at half maximum, FWHM).…”

Section: Screening Techniquesmentioning

confidence: 99%

The current role of high-resolution mass spectrometry in food analysis

Kaufmann

2011

Anal Bioanal Chem

176

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High-resolution mass spectrometry (HRMS), which is used for residue analysis in food, has gained wider acceptance in the last few years. This development is due to the availability of more rugged, sensitive, and selective instrumentation. The benefits provided by HRMS over classical unit-mass-resolution tandem mass spectrometry are considerable. These benefits include the collection of full-scan spectra, which provides greater insight into the composition of a sample. Consequently, the analyst has the freedom to measure compounds without previous compound-specific tuning, the possibility of retrospective data analysis, and the capability of performing structural elucidations of unknown or suspected compounds. HRMS strongly competes with classical tandem mass spectrometry in the field of quantitative multiresidue methods (e.g., pesticides and veterinary drugs). It is one of the most promising tools when moving towards nontargeted approaches. Certain hardware and software issues still have to be addressed by the instrument manufacturers for it to dislodge tandem mass spectrometry from its position as the standard trace analysis tool.

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Section: Screening Techniquesmentioning

confidence: 99%

The current role of high-resolution mass spectrometry in food analysis

Kaufmann

2011

Anal Bioanal Chem

176

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“…Triple quadrupole instruments provide superior selectivity and sensitivity against background noise originating from chemical and biological matrices via selected reaction monitoring ( SRM ), also called multiple reaction monitoring ( MRM ), which specifi cally monitor selected product ions generated via CID from targeted molecular ions. SRM is routinely used for in vitro ADME screening studies and quantitative bioanalysis [16,17] . Precursor ion ( PI ) scanning generates a mass spectrum which is comprised only of molecular ions that can generate a certain desired product ion.…”

Section: Triple Quadrupole Mass Spectrometrymentioning

confidence: 99%

LC‐MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective

Jian

Shou

Edom

et al. 2012

Mass Spectrometry Handbook

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“…Many reports in the literature described the use of a narrow mass window to improve selectivity. [21][22][23] Other studies have addressed the issue of the mass resolution required for trace analysis in food matrices. 24 Resolutions of 50,000 or more FWHM were suggested for low levels of analytes in complex matrices such as animal feed.…”

Section: High-resolution Acquisitionmentioning

confidence: 99%