The National Aeronautics and Space Administration Global Precipitation Measurement (GPM) mission ground validation program uses dual-polarization radar moments to estimate raindrop size distribution (DSD) parameters, the mass-weighted mean drop diameter Dmass, and normalized intercept parameter NW, to validate the GPM Core Observatory–derived DSD parameters. The disdrometer-based Dmass and NW are derived through empirical relationships between Dmass and differential reflectivity ZDR, and between NW, reflectivity ZH, and Dmass. This study employs large datasets collected from two-dimensional video disdrometers (2DVD) during six different field studies to derive the requisite empirical relationships. The uncertainty of the derived Dmass(ZDR) relationship is evaluated through comparisons of 2DVD-calculated and ZDR-estimated Dmass, where ZDR is calculated directly from 2DVD observations. Similarly, the uncertainty of the NW(ZH, Dmass) relationship is evaluated through 2DVD-calculated and Dmass and ZH-estimated NW, where Dmass and ZH are directly calculated from 2DVD observations. This study also presents the sensitivity of Dmass(ZDR) relationships to climate regime and to disdrometer type after developing three additional Dmass(ZDR) relationships from second-generation Particle Size Velocity (PARSIVEL2) disdrometer (P2) observations collected in the Pacific Northwest, in Iowa, and at Kwajalein Atoll in the tropical Pacific Ocean. The application of P2-derived Dmass(ZDR) relationship based on precipitation in the northwestern United States to P2 observations collected over the tropical ocean resulted in the highest error among comparisons of the three datasets.