2011
DOI: 10.1016/j.colsurfb.2011.02.015
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Compressibility study of quaternary phospholipid blend monolayers

Abstract: The mechanical properties of liposome membranes are strongly dependent on type and ratio of lipid compounds, which can have important role in drug targeting and release processes when liposome is used as drug carrier. In this work we have used Brewster's angle microscopy to monitor the lateral compression process of lipid monolayers containing as helper lipids either distearoyl phosphatidylethanolamine (DSPE) or dioleoyl phophatidylethanolamine (DOPE) molecules on the Langmuir trough. The compressibility coeff… Show more

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Cited by 4 publications
(2 citation statements)
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“…Depending on the type of cell, the relative amounts of each lipid species in the membrane vary, with sometimes stark differences in the quantities of saturated lipids and/or charged lipids [ 1 ]. Collectively, the lipid composition of the cell membrane determines macroscopic membrane properties such as bending rigidity ( k c ) [ 2 ], compressibility [ 3 ] and stretching modulus [ 4 ]. Such properties govern a multitude of biophysical processes, including membrane protein function [ 5 ], vitamin B12 uptake [ 6 ], and drug efficacy [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Depending on the type of cell, the relative amounts of each lipid species in the membrane vary, with sometimes stark differences in the quantities of saturated lipids and/or charged lipids [ 1 ]. Collectively, the lipid composition of the cell membrane determines macroscopic membrane properties such as bending rigidity ( k c ) [ 2 ], compressibility [ 3 ] and stretching modulus [ 4 ]. Such properties govern a multitude of biophysical processes, including membrane protein function [ 5 ], vitamin B12 uptake [ 6 ], and drug efficacy [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Fig. 1 a Molecular structure of DP; b Three types of intermolecular interactions that occur between DP and DP: (1) Head-to-head; (2) tail-to-tail; (3) head-to-tail PEG with saturated lipids, such as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-Namino(polyethylene glycol)-2000 (DSPE PEG2000), is commonly used in numerous preparations of stealth liposome (or immunoliposome) formulations for in vivo and in vitro cancer therapeutic studies [24][25][26][27][28][29][30][31]. PEGs with saturated lipids have no bends or kinks in their saturated lipid molecular structures that promote molecular packing, so they are easily inserted into the liposome membrane.…”
Section: Introductionmentioning
confidence: 99%