Concomitant development of gastrin immunoreactivity and formaldehyde-ozone-induced fluorescence in gastrin cells of rabbit antropyloric mucosa

Immunocytochemically, secretin cells have been demonstrated to occur in the duodenum and jejunum of several mammals. Calculations on the relative frequency of such cells indicate that the bulk of secretin occurs in the jejunum, a fact supporting the view that secretin may be released by physiological stimulants other than hydrochloric acid. Electron microscopical identification of cat and pig secretin cells confirmed their identity with the ultrastructurally defined S cells, and staining experiments revealed that secretin cells were argyrophilic both with the method of Grimelius and with that of Hellerström and Hellman. Secretin cells are detected already in the 17-day old fetal rat duodenum and show a developmental pattern similar to that displayed by the gastrin cells. It is suggested that secretin may play a role in the early regulation of growth of the fetal gastrointestinal tract.

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Formaldehyde-ozone-induced fluorescence in gastrin-producing tumours

Sundler

Grimelius

et al. 1975

Virchows Arch. A Path. Anat. and Histol.

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Material from eight peptide hormone-secreting tumours, extirpated from the pancreas or from the antrum-duodenum region, was examined. Four of the patients had the clinical manifestations of the Zollinger-Ellison syndrome, two showed the features of an insulin-secreting tumour and one had a glucagonoma. Gastrin-producing cells, identified by immunohistochemistry, were found in five of the tumours. These cells displayed a varying degree of formaldehyde-ozone-induced fluorescence. This agrees with previous observations on the gastrin cell of human antral and duodenal mucosa. From model experiments, formaldehyde-ozone-induced fluorescence is thought to reflect the presence of peptides having tryptophan in the NH2-terminal position. The nature of this peptide in gastrin-producing cells is unknown.

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Concomitant development of gastrin immunoreactivity and formaldehyde-ozone-induced fluorescence in gastrin cells of rabbit antropyloric mucosa

Cited by 7 publications

References 10 publications

Intestinal endocrine cells of chicks around the time of hatching

Intestinal endocrine cells of chicks around the time of hatching

Distribution, ontogeny and ultrastructure of the mammalian secretin cell

Formaldehyde-ozone-induced fluorescence in gastrin-producing tumours

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