Condition of Fagocytosis of Experimental Animals With Periodontitis Due to Modified Reactivity

Abstract

Introduction: Taking into account the patho-immune mechanisms of formation of inflammatory process in periodontium, there is a necessity for in-depth study of the pathogenesis of periodontal diseases from the position of changes in the reactivity of the organism. The aim: Carrying out a comparative estimation of phagocytic activity of leukocytes of animals with inflammation in periodontium with altered reactivity. Materials and methods: Experiments were performed on 30 white rats: Group I - 10 white rats with hypoergic reaction; Group ІІ - 10 white rats with hyperergic reaction; Group III - 10 white rats with normergic reaction - control group. Slaughter and blood sampling under thiopental anesthesia was performed 7 days after the beginning of the experiment. The percentage of phagocytic leukocytes - phagocytic index, phagocytic number were determined and the index of phagocytic activity was calculated. Results: The phagocytic index (Fi,%) decreased by 2,09 times (p <0,05) at hypoergic, it increased by 1,37 times (p <0,05) at hyperergic; the index of phagocytic activity (IFA) decreased by 1.96 times at hypoergic (p <0.05); growth was 1.94 times (p <0.05) in the hyperergic group of animals. In both experimental groups, the phagocyte number (Fu) increased by 6.25% and 41.7%, with hypoergic and hyperergic, respectively. Conclusions: Different directions of changes of the phagocytic activity were observed: increase of these parameters at hyperergic and decrease at hypoergic. An increase in phagocyte number was likely to indicate some autonomy of the process of phagocytosis and independence from the reactivity of the organism.

Динаміка Активності Фосфатаз У Сироватці Крові Та Гомогенаті Тканин Пародонта При Експериментальному Гінгівіті

“…Унаслідок значного поширення запальних захворювань тканин пародонта акту-альним питанням у стоматології залишається покращення результатів їх лікування та про-філактики. На сьогодні розробок лікування експериментального гінгівіту, спричиненого змінами реактивності організму, присвячено не так багато робіт [1,2].…”

Changes in the activity of phosphatases, calcium and phosphorus in rats with the different courses of gingivitis under correction by anti-inflammatory gel

“…In addition to local etiological factors of inflammation in periodontal tissues (dental plaque, microflora, crowded teeth, etc. ), the course of the inflammatory process is closely related to the reactivity of the body [11][12][13][14].…”

Analysis of microbiocenosis of a gingival sulcus and periodontal pockets of patients with periodontal diseases associated with systemic pathology

“…Diseases of periodontal tissues constitute a significant problem in modern society due to their widespread and progressive course as they accompany tooth loss and compromised function of the maxillofacial system, decreasing patients' life quality [1,2]. The main etiological and pathogenic factors of periodontal diseases are the aggressive microbes and their by-products [3,4]. Periodontopathogenic oral microflora is the initial mechanism of the development of chronic inflammation in periodontal tissues.…”