Conspecific infection threat rapidly biases the social responses of female mice: Involvement of oxytocin

Kavaliers, Martin; Colwell, D. D.; Wah, Deanne Tak On; Bishnoi, Indra R.; Ossenkopp, Klaus‐Peter; Choleris, Elena

doi:10.1016/j.yhbeh.2019.04.016

Cited by 11 publications

(15 citation statements)

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“…Evidently, even an indirect risk of contagion reduces the appeal of an otherwise attractive potential mate. Yet again, neither the preference for males associated with an uninfected female nor the aversion to those associated with an infected one materialize without a functioning oxytocin receptor (Kavaliers et al 2019).…”

Section: Sexual Attraction Sexual Repulsion: Biological Basesmentioning

confidence: 95%

Infection threat shapes our social instincts

Krämer

Bressan

2021

Behav Ecol Sociobiol

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We social animals must balance the need to avoid infections with the need to interact with conspecifics. To that end we have evolved, alongside our physiological immune system, a suite of behaviors devised to deal with potentially contagious individuals. Focusing mostly on humans, the current review describes the design and biological innards of this behavioral immune system, laying out how infection threat shapes sociality and sociality shapes infection threat. The paper shows how the danger of contagion is detected and posted to the brain; how it affects individuals’ mate choice and sex life; why it strengthens ties within groups but severs those between them, leading to hostility toward anyone who looks, smells, or behaves unusually; and how it permeates the foundation of our moral and political views. This system was already in place when agriculture and animal domestication set off a massive increase in our population density, personal connections, and interaction with other species, amplifying enormously the spread of disease. Alas, pandemics such as COVID-19 not only are a disaster for public health, but, by rousing millions of behavioral immune systems, could prove a threat to harmonious cohabitation too.

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Section: Sexual Attraction Sexual Repulsion: Biological Basesmentioning

confidence: 95%

Infection threat shapes our social instincts

Krämer

Bressan

2021

Behav Ecol Sociobiol

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“…Similar patterns of responses to the odors of unfamiliar and familar individuals and pathogen threat are evident in mice with the presence of infection threat biasing preferences for, approaches to, and interactions with familiar individuals and increasing the avoidance of unfamiliar individuals ( Kavaliers et al, 2019b ).). However, the nature of the infection threat and whether or not sickness behaviors are present needs to be examined before any definite conclusions can be drawn.…”

Section: Pathogen Disgust and Unfamiliar Individualsmentioning

confidence: 95%

“…Natural populations of animals exhibit complex social interactions and contact patterns and are not simple dyadic (e.g. male-female) interactions ( Altizier et al, 2003 ; Ezenwa et al, 2016 ; Kavaliers et al, 2019 ; Lopes et al, 2016 ). Across a wide range of taxa individuals that are well connected or highly central in their social networks are more likely to be infected by gastrointestinal and other parasites ( Altizier et al, 2003 ; Ezenwa et al, 2016 ; Kappeler et al, 2015 ).…”

Section: Pathogen Disgust and Social Informationmentioning

confidence: 99%

“…We recently reviewed parasite detection and avoidance in relation to mate-choice ( Kavaliers and Choleris, 2018 ; Kavaliers, Ossenkopp, and Choleris, 2019 ), and there are other reviews that have examined the topic ( Beltran-Bech and Richards, 2014 ). In the present review we address a number of basic features of odor based pathogen disgust in rodents.…”

Section: Introductionmentioning

confidence: 99%

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Pathogens, odors, and disgust in rodents

Kavaliers

Ossenkopp

Choleris

2020

Neuroscience & Biobehavioral Reviews

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Highlights Pathogen disgust is an evolutionarily conserved affective system for the recognition and avoidance of infection threat. Pathogen disgust entails a number of fundamental features (valence, scalability, flexibility, persistence). Pathogen disgust in rodents in rodents is odor mediated. Pathogen disgust involves trade-offs between the acquisition of social information/social interaction and infection. Pathogen disgust involves a number of neuromodulatory systems.

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“…断 (Białek et al, 2021)、政治决策 (Shook et al, 2017) 和种系发展 (O'Shea et al, 2019)等, 故对厌恶情绪的深入研究对个体生存和社会发展都具有重大意义。目前对厌恶的研究主要包括：厌恶的结构与分类 (Stevenson et al, 2019); 厌恶的进化功能 (Oaten et al, 2009); 厌恶表情识别 (Wicker et al, 2003); 条件性厌恶习得与表达 (Schier et al, 2019); (Weinstein et al, 2018)、厌恶与愤怒 (Molho et al, 2017); 以及厌恶与恐惧症、强迫症、进食障碍等精神类疾病的关系 (Khalil et al, 2020;Knowles et al, 2018) (Oaten et al, 2009;Weinstein et al, 2018)。这种特性具有物种上的延续性, 从龙虾、蝌蚪、蚂蚁、蜜蜂、蜗牛、鱼类、鸟类、啮齿动物、非人类灵长类动物到人类都会对感染了病原体的同伴产生厌恶反应 (Behringer et al, 2006;Kavaliers et al, 2020;Kiesecker et al, 1999) Colwell, et al, 2019)…”

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The influence of oxytocin, progesterone and estrogen on disgust and its neurophysiological mechanism

Zhang¹,

Lei²,

Wang³

2022

Adv Psychol Sci

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Disgust is an important basic emotion for human beings and animals, and it derives from distasteful oral responses to bitter (toxic) tastants, often accompanied with nausea and vomiting and a strong desire to stay away from the induced stimulus, and it has the function of avoiding potential disease threats. A large number of studies have shown that oxytocin, progesterone, and estrogens can affect perception, generation and expression of core disgust, as well as learning conditioned disgust and recognizing facial expression in varying degrees. These three hormones mainly affect the processing of disgust by modulating neurotransmitter receptors including serotonin, γ-aminobutyric acid, acetylcholine, and glutamic acid receptors, and thus affecting the activities of amygdala, insula, anterior cingulate gyrus, putamen, piriform cortex, and middle frontal gyrus. Future studies should explore the effects of these hormones on disgust in different sensory channels and also consider their moderating roles in different genders by accurately measuring hormone levels and controlling the task difficulties. In addition, researchers can combine neuroimaging technologies with behavioral studies to clarify the neuroendocrine mechanism of these hormones affecting disgust processing.

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Conspecific infection threat rapidly biases the social responses of female mice: Involvement of oxytocin

Cited by 11 publications

References 74 publications

Infection threat shapes our social instincts

Infection threat shapes our social instincts

Pathogens, odors, and disgust in rodents

The influence of oxytocin, progesterone and estrogen on disgust and its neurophysiological mechanism

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