“…Compounds were evaluated for COX inhibitory activity in vitro by using Cayman’s COX Fluorescent Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, MI, USA) as previously described methods [15].…”
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
“…Compounds were evaluated for COX inhibitory activity in vitro by using Cayman’s COX Fluorescent Inhibitor Screening Assay Kit (Cayman Chemical Company, Ann Arbor, MI, USA) as previously described methods [15].…”
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1−3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
“…The combined immunosuppressive and anti-inflammatory activity is strong evidence that polyrhadopamine C ( 18 ) could be effective against rheumatoid arthritis. Last year, an additional thirteen nitrogen containing compounds were isolated from P. dives ants and evaluated for their anti-inflammatory, immunosuppressive, and renoprotective activities 64 .Figure 4Structures of dopamine derivatives isolated from Chinese black ants.…”
Section: Hymenoptera (Bees Wasps Ants and Sawflies)mentioning
confidence: 99%
“…5) and β -carboline-3-carboxamide ( 26 ) suppressed the proliferation of T-cells, key cellular targets for rheumatoid arthritis therapy64, 65. Additionally, compounds 25 , 27 , and 3-hydroxypyridine significantly reduced collagen IV, fibronectin, and interleukin-6 (IL-6) overproduction supporting the use of the ants as a tonic for kidney problems 64 . Furthermore, compounds 25 , 26 , 29 , and 30 led to moderate inhibition of TNF- α production, compound 29 inhibited cyclooxygenase-1, and compound 28 significantly inhibited janus kinase (JAK)-3 kinase all of which indicate anti-inflammatory activity.Figure 5Structures of additional compounds isolated from Chinese black ants.…”
Section: Hymenoptera (Bees Wasps Ants and Sawflies)mentioning
Nature has been the source of life-changing and -saving medications for centuries. Aspirin, penicillin and morphine are prime examples of Nature׳s gifts to medicine. These discoveries catalyzed the field of natural product drug discovery which has mostly focused on plants. However, insects have more than twice the number of species and entomotherapy has been in practice for as long as and often in conjunction with medicinal plants and is an important alternative to modern medicine in many parts of the world. Herein, an overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented. Insect natural products reviewed were isolated from ants, bees, wasps, beetles, cockroaches, termites, flies, true bugs, moths and more. Biological activities of these natural products from insects include antimicrobial, antifungal, antiviral, anticancer, antioxidant, anti-inflammatory and immunomodulatory effects.
“…Rumpold and Schlüter (2013a) and van Huis (2013) indicate that, in totality, insects are no more hazardous as human food than conventional livestock. Studies vis a vis antinutrients also show insects to be comparable with conventional food which is popularly perceived to be more healthy and wholesome than insect-based food (Kiatbenjakul et al, 2015;Tang et al, 2015).…”
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