Abstract-In karst area, lots of piles through several caves and then supporting in a cave roof, thus forming more complex pile-soil-cave interaction. Research on the pile foundation settlement in beaded karst region, has strong theoretical and engineering significance to further improve the design theory of the pile foundation and guide the foundation design and construction. In this paper, it is found that in the stage of the construction of pile foundation, cave has little effect on the settlement. Under the upper load, the impact of the cave quantity and spacing is not significant, and the impact of the cave width is significant. In the effect of consolidation of the cave fillings, the cave has the greatest influence on the settlement. Overall speaking, the cave size has the greatest impact on the total settlement of the pile foundation, the cave quantity is the second, and the cave spacing has the minimal impact.