Contactless Electrochemical Actuator for Microfluidic Dosing

Metref, Lynda; Herrera, F.; Berdat, Daniel; Gijs, Martin A. M.

doi:10.1109/jmems.2007.892893

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…The flow rates of the syringes are set with the Nemesys software. The valve control chambers are filled with DIW to eliminate bubble creation originating from continuous gas diffusion through the thin PDMS membrane (Metref et al 2007) into the fluidic channel due to the steady pressurized air. On the other hand, the mixer control chambers that are connected also to the exhaust ports do not need to be filled with DIW, since the thin mixer control chamber membrane is not exposed to the steady pressurized air.…”

Section: Methodsmentioning

confidence: 99%

Chaotic mixing using source–sink microfluidic flows in a PDMS chip

Tekin

Sivagnanam

Çiftlik

et al. 2010

Microfluid Nanofluid

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We present an active fixed-volume mixer based on the creation of multiple source-sink microfluidic flows in a polydimethylsiloxane (PDMS) chip without the need of external or internal pumps. To do so, four different pressure-controlled actuation chambers are arranged on top of the 5 ll volume of the mixing chamber. After the mixing volume is sealed/fixed by microfluidic valves made using 'microplumbing technology', a virtual source-sink pair is created by pressurizing one of the membranes and, at the same time, releasing the pressure of a neighboring one. The pressurized air deforms the thin membrane between the mixing and control chambers and creates microfluidic flows from the squeezed region (source) to the released region (sink) where the PDMS membrane is turned into the initial state. Several schemes of operation of virtual source-sink pairs are studied. In the optimized protocol, mixing is realized in just a sub-second time interval, thanks to the implementation of chaotic advection.

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Section: Methodsmentioning

confidence: 99%

Chaotic mixing using source–sink microfluidic flows in a PDMS chip

Tekin

Sivagnanam

Çiftlik

et al. 2010

Microfluid Nanofluid

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“…Thermal and electrolytically-generated bubbles have been investigated for their utility in miniaturized pumps, microfluidic dosing experiments [ 63 ], and are favorable due to simple fabrication and ease of control. The disadvantage of thermal production of water vapor bubbles is the risk of denaturating biological molecules due to overheating [ 64 ]. In addition, the electrolytic production of bubbles has been shown to be far more energy efficient than thermal bubble generation [ 65 ].…”

Section: Microfluidic Nucleic-acid Based Pathogen Detection Systemsmentioning

confidence: 99%

Nucleic Acid-based Detection of Bacterial Pathogens Using Integrated Microfluidic Platform Systems

Lui

Cady

Batt

2009

Sensors

106

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The advent of nucleic acid-based pathogen detection methods offers increased sensitivity and specificity over traditional microbiological techniques, driving the development of portable, integrated biosensors. The miniaturization and automation of integrated detection systems presents a significant advantage for rapid, portable field-based testing. In this review, we highlight current developments and directions in nucleic acid-based micro total analysis systems for the detection of bacterial pathogens. Recent progress in the miniaturization of microfluidic processing steps for cell capture, DNA extraction and purification, polymerase chain reaction, and product detection are detailed. Discussions include strategies and challenges for implementation of an integrated portable platform.

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“…3,8,13 To date, electrochemical actuator designs have remained mostly unchanged; they consist of a pair of 2-layer metal electrodes, a layer of noble metal such as Pt/Au on the top and another layer of Ti/Cr as an adhesion layer to the substrate. [14][15][16][17][18][19][20] So far, a number of MEMS drug delivery devices using electrochemical actuators have been demonstrated, such as controlled intraocular drug release 16 and individualized cancer drug treatment. 21,22 An interdigitated electrode pattern is widely used in fabricating a conventional electrochemical actuator and it is simple and straightforward to fabricate.…”

Section: Introductionmentioning

confidence: 99%

High reliability nanosandwiched Pt/Ti multilayer electrode actuators for on-chip biomedical applications

Tng

Song

et al. 2014

Analyst

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Microactuators provide the main driving force for fluid pumping in microfluidic devices and thus play an important role in on-chip biomedical applications. Interdigitated electrode based electrochemical actuators have provided a viable choice for effective actuation with advantages of flexible controllability, biocompatibility and ease of fabrication. However, the current feature size of a typical electrode structure is around 100 μm, which is relatively large for device miniaturization and integration. Further decrease in the feature size will lead to dramatic decrease in the reliability and lifetime of the actuators, caused by metal delamination. In this work, we propose a novel design of electrodes to fabricate a new type of microactuator with high reliability. To prevent the occurrence of delamination, a nanosandwiched multilayer structure of titanium/platinum is used to construct the conductive metal layer for the interdigitated electrodes. The feature size of the electrodes is greatly reduced to 20 μm where we have reduced the size by 80% of the similar structures reported previously. At the same time, the lifetime of the new electrodes has been dramatically increased to over 400% as compared to the conventional design. With these remarkable improvements in the electrode design, we have fabricated a prototype microfluidic device integrating the new microactuator for drug tests in cancer therapy, demonstrating its usefulness for on-chip biomedical applications.

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Contactless Electrochemical Actuator for Microfluidic Dosing

Cited by 7 publications

References 24 publications

Chaotic mixing using source–sink microfluidic flows in a PDMS chip

Chaotic mixing using source–sink microfluidic flows in a PDMS chip

Nucleic Acid-based Detection of Bacterial Pathogens Using Integrated Microfluidic Platform Systems

High reliability nanosandwiched Pt/Ti multilayer electrode actuators for on-chip biomedical applications

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