1997
DOI: 10.1016/s0167-8140(97)01934-8
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Continuous, pulsed or single acute irradiation of a transplanted rodent tumour model

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Cited by 10 publications
(6 citation statements)
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“…Radiobiological studies showed, that PDR brachytherapy is probably equivalent to LDR brachytherapy models [1,5,7,10,12,13,17,19,24,29,32,42]. Initial clinical data for different clinical situations provided some evidence to support this hypothesis [8,9,11,15,18,21,26,30,31,34,36,37,39,40,43].…”
Section: Discussionmentioning
confidence: 99%
“…Radiobiological studies showed, that PDR brachytherapy is probably equivalent to LDR brachytherapy models [1,5,7,10,12,13,17,19,24,29,32,42]. Initial clinical data for different clinical situations provided some evidence to support this hypothesis [8,9,11,15,18,21,26,30,31,34,36,37,39,40,43].…”
Section: Discussionmentioning
confidence: 99%
“…Experimental animal results comparing PDR with CLDR have mostly given results showing similar effects in a vari ety of normal tissues for equal doses in the same overall times [5,8,23,27]; but some tumours have demonstrated Table 1 Pulsed dose rale irradiations at medium dose rate of 4 Gy/h within pulses. Doses quoted do not include the 15 Gy X-ray top-up dose 4 F/day at 3 h intervals 9 F/day at 1 h intervals (9 h overall/day) ( either less [27] or more effects [34] of the PDR, For late rectal injury in rats, Armour et al [5] showed PDR to become more effective than CLDR only for doses per pulse above 1.5 Gy, in general agreement with theoretical predictions.…”
Section: Introductionmentioning
confidence: 61%
“…In their study, the cellular response depended on the total dose and showed no significant difference between the different fraction schedules. Sethi et al have found the apparent isoeffectiveness of tumor response to single (acute) and pulsed dose irradiations maintaining the same daily dose rate using a rat sarcoma (17). These data suggest that either the repair capacity is impaired or the effect of rapid repair is offset by the reoxygenation of hypoxic tumor cells.…”
Section: Discussionmentioning
confidence: 97%