Controlled release behavior of bioactive molecules from photo-reactive hyaluronic acid-alginate scaffolds

Nam, Hye Sung; An, Jeong Ho; Chung, Dong June; Kim, Ji Heung; Chung, Chong Pyoung

doi:10.1007/bf03218720

Cited by 26 publications

(8 citation statements)

References 24 publications

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“…In addition, the semi-IPNs were suitable to enable fibroblast , and chrondrocyte encapsulation and subsequent proliferation. HA has also been combined with alginate and poly- l -lysine − to develop scaffolds for a variety of tissue engineering applications including nerve regeneration . More recently, composite scaffolds were also prepared starting from complementary chemical functionalities.…”

Section: Biopolymer-based Hydrogel Systemsmentioning

confidence: 99%

Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review

2011

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Hydrogels are physically or chemically cross-linked polymer networks that are able to absorb large amounts of water. They can be classified into different categories depending on various parameters including the preparation method, the charge, and the mechanical and structural characteristics. The present review aims to give an overview of hydrogels based on natural polymers and their various applications in the field of tissue engineering. In a first part, relevant parameters describing different hydrogel properties and the strategies applied to finetune these characteristics will be described. In a second part, an important class of biopolymers that possess thermosensitive properties (UCST or LCST behavior) will be discussed. Another part of the review will be devoted to the application of cryogels. Finally, the most relevant biopolymer-based hydrogel systems, the different methods of preparation, as well as an in depth overview of the applications in the field of tissue engineering will be given.

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Section: Biopolymer-based Hydrogel Systemsmentioning

confidence: 99%

Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review

2011

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“…In particular, photoresponsive materials have advantages in remote controllability by light, aiming toward the development of photocontrolled-release biorelated materials that are preferably composed of biocompatible molecules such as polysaccharides. The photoresponsive polysaccharide gels were conventionally prepared by the incorporation of photoreactive moieties. − In particular, uronic acid is a kind of ultraviolet absorbable sugar that was contained in various polysaccharides such as glycosaminoglycans (GAGs); then, it has been reported that the decarboxylation of uronic acid occurred due to photoirradiation . The photoirradiation to GAGs containing uronic acid causes their degradation accompanied with the reduction of the molecular weight and viscosity. − It is difficult to prepare self-supporting hydrogel materials of simple GAGs in vitro because they do not have a sufficiently high molecular weight and the formation of a 3D network is difficult.…”

Section: Introductionmentioning

confidence: 99%

Photoshrinkage in Polysaccharide Gels with Trivalent Metal Ions.

et al. 2012

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The giant anionic polysaccharide "sacran", which is composed of 6-deoxyhexoses, pentoses, uronic acids as well as hexoses, showed hydrophobization and insolubilization phenomena in response to ultraviolet light irradiation. The sacran solution became turbid, and microparticles were formed by photoirradiation. To visualize the results of this photoreaction, anionic polysaccharide gels cross-linked by metal cations were used. As a result, we observed that sacran-gels with trivalent metal ions gradually contracted depending on the photoirradiation energy. In contrast, alginate gels used as a comparison degraded instead of contracting. This photoshrinkage of the sacran gels may be attributed to the hydrophobization of uronic acid based on photodecarboxylation. We propose that sacran-metal ion gels can function as effective, photoresponsive gels.

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“…Also, the release amount of CNF/CS beads (8:2) in the first 1 h of releasing under acid conditions (14.5%) was lower than other reported TH carriers, such as polydopamine/CNF hydrogel (20%) [ 6 ], collagen hydrogel (42%) [ 32 ], polycarboxybetaine hydrogel (35%) [ 33 ], and hyaluronic acid/alginate scaffolds (50%) [ 34 ]. Simultaneously, the total release amount of TH from CNF/CS beads (8:2) (88%) was higher than many reported TH carriers, such as polydopamine/CNF hydrogel (77%) [ 6 ], collagen hydrogel (50%) [ 32 ], and cellulose nanocrystal (82.2%) [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

Deng

Zhang

et al. 2022

Polymers

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It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.

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Controlled release behavior of bioactive molecules from photo-reactive hyaluronic acid-alginate scaffolds

Cited by 26 publications

References 24 publications

Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review

Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review

Photoshrinkage in Polysaccharide Gels with Trivalent Metal Ions.

Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers

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