2005
DOI: 10.1016/j.biomaterials.2004.09.048
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Cooperative modulation of neuritogenesis by PC12 cells by topography and nerve growth factor

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Cited by 143 publications
(130 citation statements)
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“…Indirect patterning of the silicone surface as generated by molding guided neurites of both cell types in parallel to the grooves, as also observed earlier in various other studies on PC-12 cells 30,31 and primary isolated neuronal cells such as CNS neuroblasts 25 and hippocampal cells. 35 However, in our study microstructures generated by direct laser ablation did not influence the direction of neurite outgrowth in either of the two cell types.…”
Section: Discussionsupporting
confidence: 75%
See 1 more Smart Citation
“…Indirect patterning of the silicone surface as generated by molding guided neurites of both cell types in parallel to the grooves, as also observed earlier in various other studies on PC-12 cells 30,31 and primary isolated neuronal cells such as CNS neuroblasts 25 and hippocampal cells. 35 However, in our study microstructures generated by direct laser ablation did not influence the direction of neurite outgrowth in either of the two cell types.…”
Section: Discussionsupporting
confidence: 75%
“…However, a few studies found perpendicular orientations. 23,25 Therefore we compared the neuronal-like cell line PC-12 [30][31][32] with the primary SGCs isolated from the inner ear. Thus, surface structures were manufactured that could guide neuronal cell growth in the direction of the platinum contact material and could be used to minimize the distance between the neuronal cells and the electrode contact.…”
Section: Introductionmentioning
confidence: 99%
“…PC12 rat pheochromocytoma cells are widely used in investigating neural behavior because of they would express some neural characteristics reversibly when expose to growth factor supplement. On the whole, PC12 cells grow in the culture medium containing 50 ng/mL NGF resulted the mitosis and spread the cellular structure that are morphological correspondent with primary sympathetic neurons [4].…”
Section: Introductionmentioning
confidence: 99%
“…Microscale and nanoscale topographies have been found to induce reorientation and differentiation of multiple cell types, including neural progenitor cells [62], astroglial cells [70], smooth muscle cells [71] and mesenchymal stem cells [72]. Furthermore, surface topography can direct cell morphologic adaptations and subsequent changes in protein expression levels [62,[73][74][75][76]. Surface topographic cues similar to endogenous ECM can direct cell morphogenesis via cell-surface contact [60,75].…”
Section: Surface Topographymentioning
confidence: 99%
“…Furthermore, surface topography can direct cell morphologic adaptations and subsequent changes in protein expression levels [62,[73][74][75][76]. Surface topographic cues similar to endogenous ECM can direct cell morphogenesis via cell-surface contact [60,75]. It is suggested that the influence of surface topography on differentiation is via cell-cell surface receptors which act as mechanochemical transducers, activating signal transduction pathways and ultimately modulating gene expression and protein expression [76].…”
Section: Surface Topographymentioning
confidence: 99%